The expansive role of oxylipins on platelet biology

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Jennifer YeungMichael Holinstat

Abstract

In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) from polyunsaturated fatty acids (PUFAs) which exhibit pro- or anti-thrombotic activity. Over the years, novel oxylipins generated from the interplay of theoxygenase activity in various cells, such as the specialized pro-resolving mediators (SPMs), have been identified and investigated in inflammatory disease models. Although platelets have been implicated in inflammation, the role and mechanism of these SPMs produced from immune cells on platelet function are still unclear. This review highlights the burgeoning classes of oxylipins that have been found to regulate platelet function; however, their mechanism of action still remains to be elucidated.

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Citations

Apr 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ivan LiakhAdriana Mika
Jun 22, 2018·Pharmacological Reviews·Jennifer YeungMichael Holinstat
May 15, 2020·Journal of Lipid Research·Steven C PerryTheodore R Holman
Jul 22, 2020·Journal of Clinical Laboratory Analysis·Feng ZhangPhilipp-Alexander Neumann
May 12, 2019·Digestive Diseases and Sciences·Bei GaoBernd Schnabl
Jul 2, 2017·Cancer Metastasis Reviews·Michael Holinstat
Jul 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adam R Offenbacher, Theodore R Holman
Nov 8, 2019·Blood·Michael Holinstat
Jan 29, 2020·Research and Practice in Thrombosis and Haemostasis·Ben DriverDianne E van der Wal
Nov 23, 2020·Journal of Thrombosis and Haemostasis : JTH·Adriana YamaguchiMichael Holinstat
Jan 13, 2021·Metabolites·Nikhil RangholiaStephen P Holly
Jan 29, 2020·Transfusion Medicine Reviews·Sarah M GreenLacey Johnson
Dec 3, 2020·International Journal of Molecular Sciences·Steffen BrauneFriedrich Jung
Mar 4, 2021·Metabolites·Kristen J PolinskiJill M Norris
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Apr 4, 2021·International Journal of Molecular Sciences·Nina ĐukanovićZoran Todorović
Jul 3, 2021·International Journal of Molecular Sciences·Kamila P LiputMariusz Pierzchała
Aug 2, 2021·Transfusion Medicine Reviews·Swarni ThakarDonald M Arnold

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