The experimental inoculation with Mycobacterium leprae in autoimmune mice: results of MRL/lpr mice inoculated into the right hind foot (continued)

Nihon Rai Gakkai zasshi
Y YogiA Suzuki

Abstract

Using MRL/lpr, NOD and Crj:CD-1 (ICR) mice, inoculations of M. leprae were made into the right hind foot at a dose of 5.8 x 10(6) bacilli per foot in order to study the influence of the immunobiological characteristics of their mice on the growth of M. leprae. To summarize of the results, MRL/lpr mice showed the high susceptibility to M. leprae, while that of NOD mice were poor. In conclusion, the immunobiological characteristics of MRL/lpr, autoimmune mice bearing lpr gene had effect on the multiplication of M. leprae, this mouse is a suitable multibacillary model for the study of leprosy.

Citations

Dec 1, 1995·Diabetes/metabolism Reviews·A G Baxter, A Cooke
Dec 3, 2003·História, ciências, saúde--Manguinhos·Laurinda Rosa MacielMariana Santos Damasco
Jan 26, 2021·Journal of Translational Autoimmunity·Michael Battaglia, Lee Ann Garrett-Sinha

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