The experimental model of nephrotic syndrome induced by Doxorubicin in rodents: an update

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Wagner de Fátima PereiraAna Cristina Simões e Silva

Abstract

Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia, generalized edema, and hyperlipidemia. It begins by changes in the glomerular filtration barrier, with increased permeability to plasma proteins. It affects all age groups and can progress to end-stage renal disease. NS pathophysiology is still unknown. However, the critical role of the immune system is well recognized. Animal models are useful tools for the investigation of NS. Among different experimental models proposed in the literature, disease induced by Doxorubicin has been considered helpful to the purpose of many studies. The aim of this review article is to describe the animal model of NS induced by the injection of Doxorubicin in rodents, with emphasis on action of the drug, potential mechanisms of renal injury, as well biochemical, histological, and corporal changes obtained with this model.

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Citations

Sep 12, 2015·Human Molecular Genetics·J Nicholas CochranErik D Roberson
Jun 13, 2015·Mediators of Inflammation·Wagner de Fátima PereiraAna Cristina Simões e Silva
Aug 23, 2018·International Journal of Molecular Medicine·Peipei ChenXuemei Li
May 14, 2016·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Na WangXiang-mei Chen
Jul 19, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wei ZouMenghua Liu

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