PMID: 12761972May 24, 2003Paper

The experimental study of intratemporal facial nerve regeneration in chitin chamber

Zhonghua er bi yan hou ke za zhi
Ping CaiB Xiao

Abstract

To investigate the feasibility of intratemporal facial nerve regeneration in a chitin chamber. A left 6 mm intratemporal facial nerve gap was created in adult white rabbit, and a total of 48 animals were used. The proximal and distal stumps were bridged with chitin chamber (experimental group) and silicone chamber (control group). Regeneration of the nerve was assessed by gross observation, nerve electrophysiological test, histological examination and digital morphological analysis in both groups. 1. Three months after implantation, the proximal transected neural stump was connected with the distal stump in the chitin chamber. Five months after operation, the regenerated nerve exhibited a more nature fascicular organization and the chitin tubes were completely absorbed. 2. Nerve evoked potentials showed better conduction ability in the chitin chamber. There were no significant difference in electrophysiological indices between the two chamber groups. 3. Most of the regenerated nerve fibers were myelinated nerve fibers, and axons and myelins had similar histograms between the experimental and control groups. 4. Five months after operation, the mean percentage of recovery of the regenerated nerve fiber area, axonal area and axona...Continue Reading

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