PMID: 6401318Jan 1, 1983Paper

The export of immunoglobulin D by human neoplastic B lymphocytes

The Journal of Experimental Medicine
F K StevensonA L Tutt

Abstract

An investigation has been made into the ability of human neoplastic B lymphocytes expressing surface IgM and IgD to export IgD in culture. Cells that expressed surface Ig of the lambda light chain type frequently exported IgD (10/12 patients), whereas cells expressing surface Ig of the kappa light chain type exported no IgD, although most (8/11 patients) were able to export IgM. It appears, therefore, that in most of the 23 cases studied, cells synthesizing IgD with lambda light chains can both express and export IgD, whereas those synthesizing IgD kappa can only insert it into the surface membrane. This finding and the known preponderance of lambda in plasma IgD imply that the possession of a lambda chain facilitates the IgD secretory pathway, a conclusion that implicates a control mechanism subsequent to the surface/secretory dichotomy arising from different splicings of heavy chain messenger RNA.

References

Jan 1, 1977·Immunological Reviews·H L Spiegelberg
Jan 1, 1979·Scandinavian Journal of Immunology·G CorteM Ferrarini
Oct 1, 1973·The Journal of Experimental Medicine·D S RoweB Pernis
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K W MooreL E Hood
Feb 1, 1980·The American Journal of Medicine·A C AisenbergN L Harris
Dec 1, 1980·The Journal of Experimental Medicine·F K StevensonA L Tutt
Dec 1, 1981·The Journal of Experimental Medicine·F K StevensonG T Stevenson

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Citations

Jan 1, 1983·Springer Seminars in Immunopathology·G T Stevenson, F K Stevenson
Dec 16, 1983·Journal of Immunological Methods·N R Ling
Sep 1, 1991·Biological Chemistry Hoppe-Seyler·R J FriedrichN Hilschmann

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