PMID: 8598558Mar 1, 1996Paper

The expressed protein in glyphosate-tolerant soybean, 5-enolpyruvylshikimate-3-phosphate synthase from Agrobacterium sp. strain CP4, is rapidly digested in vitro and is not toxic to acutely gavaged mice

The Journal of Nutrition
L A HarrisonS R Padgette

Abstract

The safety of 5-enolpyruvylshikimate-3-phosphate synthase enzyme derived from Agrobacterium sp. strain CP4 (CP4 EPSPS) was assessed. CP4 EPSPS is the only protein introduced by genetic manipulation that is expressed in glyphosate-tolerant soybeans, which are being developed to provide new weed-control options for farmers. Expression of this protein in plants imparts high levels of glyphosate tolerance. The safety of CP4 EPSPS was ascertained by evaluating both physical and functional characteristics. CP4 EPSPS degrades readily in simulated gastric and intestinal fluids, suggesting that this protein will be degraded in the mammalian digestive tract upon ingestion as a component of food or feed, There were no deleterious effects due to the acute administration of CP4 EPSPS to mice by gavage at a high dosage of 572 mg/kg body wt, which exceeds 1000-fold tha anticipated consumption level of food products potentially containing CP4 EPSPS protein. CP4 EPSPS does not pose any important allergen concerns because this protein does not possess characteristics typical of allergenic proteins. These data, in combination with seed compositional analysis and animal feeding studies, support the conclusion that glyphosate-tolerant soybean are a...Continue Reading

Citations

Jun 5, 2002·Current Opinion in Allergy and Clinical Immunology·Steve L Taylor, Susan L Hefle
May 14, 2005·Archives of Animal Nutrition·Gerhard FlachowskyKaren Aulrich
Apr 28, 2006·Applied Microbiology and Biotechnology·Om V SinghRakesh K Jain
Jul 31, 2007·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Yoshimitsu SakamotoHisashi Kamimura
Jan 16, 2014·Journal of Food Science and Technology·A S Bawa, K R Anilakumar
Jun 4, 2002·Nature Biotechnology·Philip J DaleEliana M G Fontes
Apr 10, 2004·Toxicological Reviews·Daniel L Sudakin
Sep 13, 2008·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Yoshimitsu SakamotoAkio Ogata
Oct 27, 2007·International Journal of Toxicology·Bryan Delaney
Jun 19, 2008·Current Opinion in Allergy and Clinical Immunology·Barbara K Ballmer-Weber, Stefan Vieths
Jan 1, 2011·Environmental Biosafety Research·Morven Mc Lean
Jun 13, 2015·Science and Engineering Ethics·Ronnie Hawkins
Jul 7, 2001·Archives of Pharmacal Research·H S ChangD H Nam
Jul 3, 2002·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Haruyo OkunukiJun-ichi Sawada
May 29, 2003·The Journal of Nutrition·Harold A RichardsC Neal Stewart
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·V TufarelliV Laudadio
Nov 12, 2016·Human & Experimental Toxicology·S H ZyoudW M Sweileh
Sep 29, 2001·The Plant Journal : for Cell and Molecular Biology·H A KuiperE J Kok
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Steve L Taylor
Jan 17, 2009·Nutrition Reviews·Javier A Magaña-Gómez, Ana M Calderón de la Barca
Nov 3, 2016·Biological & Pharmaceutical Bulletin·Osamu NakajimaKazunari Kondo
Sep 3, 2018·Transgenic Research·Parimala ChinnaduraiLuis A Burzio
Sep 30, 2004·Journal of Dairy Science·A R CastilloG F Hartnell
Nov 8, 2007·Critical Reviews in Food Science and Nutrition·José L Domingo
Mar 15, 2003·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Yukihiro GodaMasatake Toyoda
Aug 11, 2006·Journal of Environmental Quality·Antonio L Cerdeira, Stephen O Duke
Oct 24, 2002·Archiv für Tierernährung·Mária ChrenkováMiroslava Prostredná
Nov 29, 2007·Journal of Applied Toxicology : JAT·Javier A Magaña-GómezAna M Calderón de la Barca
Sep 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qasim AliAbdul Qayyum Rao
May 10, 2001·The Journal of Allergy and Clinical Immunology·S L Taylor, S L Hefle
Jul 10, 2003·Journal of Agricultural and Food Chemistry·Paul B BrownThomas E Nickson
Aug 9, 2011·Journal of Agricultural and Food Chemistry·Gustavo FermínSavarni Tripathi
Mar 20, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bryan DelaneyUNKNOWN ILSI International Food Biotechnology Committee Task Force on Protein Safety
Jul 19, 2008·Journal of Agricultural and Food Chemistry·Jin ZhuPatrick J Tranel
Sep 14, 2006·Journal of Agricultural and Food Chemistry·Melinda C McCannMargaret A Nemeth

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