PMID: 30014629Jul 18, 2018Paper

The Expression and Biological Function of claudin-23 in Colorectal Cancer

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Wei ChenJin-Lin Yang

Abstract

To determine the expression of claudin-23 in colorectal cancer and paracarcinoma tissues,and its effects on the proliferation and migration of colorectal cancer cells. Six pairs of samples of colorectal cancer and corresponding paracarcinoma tissues were collected from the West China Hospital of Sichuan University. Quantitative real time PCR was performed to determine the expression of claudin-23 in the tissue samples. Colorectal cancer cell lines with stable overexpression of claduin-23 were constructed using lentivirus. CCK-8 and migration assays were conducted to identify the effects of claudin-23 on cell proliferation and migration. The expression of claudin-23 in colorectal cancer tissues decreased compared with their adjacent normal tissues (P<0.05). claudin-23 decreased cell adhesion and increased cell proliferation in HCT15 cells. RKO and HCT15 cells with over expressed claudin-23 had increased ability of migration. claudin-23 facilitates the migration ability of colorectal cancer cells and may participate in the metastasis of colorectal cancer.

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.