The expression and biological information analysis of miR-375-3p in head and neck squamous cell carcinoma based on 1825 samples from GEO, TCGA, and peer-reviewed publications

Pathology, Research and Practice
Wei-Ning CenFu-Chao Ma

Abstract

The specific expression level and clinical significance of miR-375-3p in HNSCC had not been fully stated, as well as the overall biological function and molecular mechanisms. Therefore, we purpose to carry out a comprehensive meta-analysis to further explore the clinical significance and potential function mechanism of miR-375-3p in HNSCC. HNSCC-related data was gained from Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and peer-reviewed journals. A meta-analysis was carried out to comprehensively explore the relationship between miR-375-3p expression level and clinicopathological features of HNSCC. And summary receiver operating characteristic (SROC) curve analysis was applied for evaluating disease diagnosis value of miR-375-3p. In addition, a biological pathway analysis was also performed to assess the possible molecular mechanism of miR-375-3p in HNSCC. A total of 24 available records and references were added into analysis. The overall pooled meta-analysis outcome revealed a relatively lower expression level of miR-375-3p in HNSCC specimens than that in non-cancerous controls (P < 0.001). And SROC curve analysis showed that the pooled area under the SROC curve (AUC) was 0.90 (95%CI: 0.88-0.93). In addition,...Continue Reading

Citations

Feb 15, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G-H ZhangG-J Yue
Nov 27, 2019·Journal of Clinical Medicine·Alexandra Iulia Irimie-AghiorghieseiIoana Berindan-Neagoe
Feb 6, 2020·Frontiers in Cell and Developmental Biology·Caterina Mancarella, Katia Scotlandi
Oct 18, 2020·Medicina·Cintia M Chamorro PetronacciMario Pérez Sayáns
Oct 2, 2021·Archives of Toxicology·Yuhui YuMinjie Chu

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