The Expression and Functional Significance of Vascular Endothelial-Cadherin, CD44, and Vimentin in Oral Squamous Cell Carcinoma

Journal of International Society of Preventive & Community Dentistry
Soussan Irani, Arash Dehghan

Abstract

Ninety percent of head and neck cancers are squamous cell carcinoma which develops in the oral cavity. Metastasis is the main causative factor for death in 90% of all cancer-related deaths and begins with the invasion of tumor cells through the walls of small blood vessels or lymph vessels. A growing body of evidence has shown that vasculogenic mimicry (VM) facilitates tumor growth and cancer metastasis. The current study aimed to present the role of vascular endothelial (VE)-cadherin, CD44, and vimentin in inducing VM and epithelial-mesenchymal transition (EMT) and to identify the cancer stem cell (CSC) niche in different grades of oral squamous cell carcinoma (OSCC). A total of 63 OSCC samples (21 samples each grade) were collected from the archive of Pathology Department of Besat educational hospital, Hamadan, Iran, from 2000 to 2015. VE-cadherin, CD44, and vimentin/periodic acid-Schiff (PAS) double-staining were used to validate VM. VM was identified by the detection of PAS-positive loops surrounded by tumor cells. Chi-square test was used to examine the differences between the variables. Significant level was set at 0.05. Pearson's correlation was used to assess the co-localization of the markers. There were statistically ...Continue Reading

References

Jun 15, 2018·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Soussan Irani, Bahar Jafari

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Citations

Jun 15, 2018·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Soussan Irani, Bahar Jafari
Aug 25, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Li ChenQuan Wei
Sep 8, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alison E PattesonPaul A Janmey
May 6, 2021·Cells·Fengkai LiSuling Liu

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Methods Mentioned

BETA
light microscopy

Software Mentioned

SPSS
PASS

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