The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma

Technology in Cancer Research & Treatment
Ning WuZhi-ming Chen

Abstract

The abnormal phosphatase and tensin homolog expression and activated phosphoinositide-3 kinase/Protein kinase B (AKT)/mammalian target of rapamycin signaling pathway are involved in the progression of esophageal squamous cell carcinoma. By assessing the expression pattern of key components in the phosphoinositide-3 kinase/AKT/mammalian target of rapamycin signaling pathway by immunohistochemistry in tumor and nontumor esophageal mucosa from patients with esophageal squamous cell carcinomas, we aimed to carefully explore the relationship between the various protein expressions and clinicopathological factors, as well as patient outcome. A total of 145 tumor and 145 nontumor samples from patients with esophageal squamous cell carcinoma, collected from HuaShan Hospital (Shanghai, China) were evaluated. Clinical characteristics, the targeted protein expressions (including phosphatase and tensin homolog, phosphoinositide-3 kinase, AKT, p-AKT, mammalian target of rapamycin, p-mTOR, p70S6 kinase 1, p-P70S6K1, elongation initiation factor 4E binding protein-1, and p-4E-BP1, and survival rate were analyzed. Among them, phosphoinositide-3 kinase, AKT, p-AKT, mammalian target of rapamycin, p-mTOR, elongation initiation factor 4E binding p...Continue Reading

References

Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
Nov 18, 2008·Cancer Treatment Reviews·Alex S StrimpakosKostas N Syrigos
Jan 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michelle A T HildebrandtXifeng Wu
Apr 3, 2009·Nature Reviews. Molecular Cell Biology·Xiaoju Max Ma, John Blenis
Apr 30, 2013·Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists·Dariusz WaniczekJerzy Arendt
Mar 13, 2014·British Journal of Cancer·K MalinowskyK-F Becker
Apr 2, 2014·Nature Genetics·De-Chen LinH Phillip Koeffler
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Sep 12, 2015·BioMed Research International·Jianjun LuYiyan Lei
Jul 1, 2014·Thoracic Cancer·Wanqing ChenQinghua Zhou
Sep 12, 2016·Trends in Immunology·Nyamdelger SukhbaatarThomas Weichhart
Jan 13, 2018·Cancers·Mathieu PaquetteArnim Pause

❮ Previous
Next ❯

Citations

Dec 11, 2019·British Journal of Cancer·Vittoria RaimondiVincenzo Ciminale
Jan 16, 2021·General Thoracic and Cardiovascular Surgery·Seiya InoueAkira Tangoku
Feb 13, 2021·International Journal of Molecular Sciences·Nadezhda V Popova, Manfred Jücker

❮ Previous
Next ❯

Methods Mentioned

BETA
dissections

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Related Papers

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Luís Silva MonteiroCarlos Lopes
International Journal of Clinical and Experimental Pathology
Shir-Hwa UengChuen Hsueh
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Kai-Yu HanJia-Ning Li
© 2022 Meta ULC. All rights reserved