The expression and prognostic significance of hepatoma-derived growth factor in oral cancer

Oral Oncology
Yu-Wei LinMing-Hong Tai

Abstract

Hepatoma-derived growth factor (HDGF) participates in oncogenic progression and represents a prognostic factor in several types of cancer. This study aimed to elucidate the role of HDGF during oral carcinogenesis. HDGF expression and the tumorigenic behaviors in human oral cell lines were investigated by immunoblotting, invasion and colony formation assays. Recombinant adenovirus vectors were employed to modulate the HDGF level in oral cancer cells. Immunohistochemical analysis using tissue microarray (TMA) consisting of surgically resected samples from 95 oral cancer patients was performed to delineate the correlation between HDGF expression and clinic-pathological parameters. HDGF expression was higher in malignant oral cancer cells than benign ones. Adenovirus-mediated HDGF overexpression and knockdown demonstrated the cellular HDGF level regulated the tumorigenic behaviors of oral cancer cells. Immunohistochemical analysis revealed increased HDGF expression in the nucleus and cytoplasm in oral cancer tissues. The nuclear HDGF expression was significantly correlated with tumor stage (P=0.004) and grade (P=0.013) while the cytoplasmic HDGF expression was associated with tumor necrosis (P=0.002). Kaplan-Meier analysis revealed...Continue Reading

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Citations

Jul 30, 2014·World Journal of Gastroenterology : WJG·Feng TaoWei Wang
Nov 28, 2015·Apoptosis : an International Journal on Programmed Cell Death·Karuna GiriY S Prakash
Feb 5, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianming TangAnjia Han
Sep 23, 2014·Future Oncology·Cihang BaoYufeng Cheng
Nov 13, 2019·BMC Cancer·Yu-Wei LinMing-Hong Tai
Mar 17, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Ci-Hang BaoYu-Feng Cheng
Jan 15, 2021·The Journal of Surgical Research·Xiaojie WangXiaolei Liu
Mar 30, 2021·Journal of Proteome Research·Chao-Jung ChenChiu-Ching Huang
Feb 27, 2014··Yih-Chih HsuRumwald Leo G. Lecaros

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