Abstract
To detect the expression of multidrug resistance molecules P-glycoprotein (P-gp), Lung resistnce protein (LRP) and Multidrug resistance-associated protein (MRP) and analyze the relationship between them and the clinico-pathological features. The expressions of P-gp, LRP and MRP in formalin-fixed paraffin-embedded tissue sections from 59 gastric cancer patients were determined by a labbelled Streptavidin-Peroxidase (SP) immunohistochemical technique, and the results were analyzed in correlation with clinicopathological data. None of these patients received chemotherapy prior to surgery. The positive rates of P-gp, LRP, MRP were 86.4%, 84.7% and 27.1%, respectively. The difference between the positive rate of P-gp and MRP was significant statistically, as well as the difference between the expression of MRP and LRP. No significant difference was observed between P-gp and LRP, but the positively correlation between the expression of P-gp and LRP had been found. No significant correlation between the expression of P-gp, LRP, MRP and the grade of differentiation were observed. The expression of P-gp was correlated with clinical stages positively (r = 0.742), but the difference with the expression of P-gp in different stages was not ...Continue Reading
References
Jun 10, 1998·Cancer Chemotherapy and Pharmacology·Y MasudaT Ohnuma
May 20, 1999·Surgery Today·D AlexanderS Kasai
Jan 19, 2000·Trends in Biochemical Sciences·R W JohnstoneM J Smyth
Mar 29, 2001·Medical Mycology·S K Katiyar, T D Edlind
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Oct 25, 2003·Oncogene·Suresh V AmbudkarMichael M Gottesman
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Apr 23, 2005·Cancer Biology & Therapy·Jingping DuDaiming Fan
Jul 18, 2006·Current Drug Targets·S NobiliE Mini
Aug 25, 2006·Journal of Gastroenterology and Hepatology·Bo FengZheng-Gang Zhu
Apr 13, 2007·Cell Biology International·Ying HanDaiming Fan
Apr 13, 2007·Leukemia·D Steinbach, O Legrand
Oct 20, 2007·Expert Review of Anticancer Therapy·Dexin Zhang, Daiming Fan
Nov 6, 2007·The New England Journal of Medicine·Shinichi SakuramotoUNKNOWN ACTS-GC Group
Feb 1, 2008·Biochemical Pharmacology·Robert W RobeySusan E Bates
Apr 30, 2008·Cancer Investigation·Hongcan ShiKang Wang
Jul 18, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A CervantesE Rodríguez-Braun
Nov 26, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Arzu SaglamAysegul H Uner
Feb 5, 2009·Journal of Experimental & Clinical Cancer Research : CR·Camtu D TruongDongfeng Tan
Mar 10, 2009·Journal of Experimental & Clinical Cancer Research : CR·Luigi Di LauroMassimo Lopez
Mar 11, 2009·The Journal of Pathology·Ye ZhangYunpeng Liu
Mar 25, 2009·Journal of Children's Orthopaedics·Rolf D BurghardtDror Paley
Mar 31, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y KoderaUNKNOWN Chubu Clinical Oncology Group
Apr 22, 2009·International Journal of Cancer. Journal International Du Cancer·Paola BertuccioCarlo La Vecchia
May 15, 2009·Histopathology·Areeg FaggadCarsten Denkert
Sep 11, 2009·Journal of Experimental & Clinical Cancer Research : CR·Fu-Ming QiuJian Huang
Feb 25, 2011·Future Oncology·Florian Lordick
May 31, 2015·Medical Oncology·Meng QiuCheng Yi
Feb 10, 2016·Technology in Cancer Research & Treatment·Liming XuShaofeng Wang
Citations
Mar 9, 2013·Cell Biochemistry and Biophysics·Ye Zhang, Qiong Wang
Feb 26, 2010·Journal of Experimental & Clinical Cancer Research : CR·Long WuYan Li
Nov 1, 2011·Journal of Experimental & Clinical Cancer Research : CR·Yun HeGuanghui Wei
Jul 1, 2015·Cancer Biology & Therapy·Anita MangiaNicola Silvestris
Jul 26, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hao LaiJiansi Chen
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hua SuiQi Li
Oct 26, 2016·Veterinary and Comparative Oncology·R FinotelloL Ressel
Feb 6, 2016·Scientific Reports·Dongsheng HuangZhongsheng Zhao
Oct 27, 2015·Molecular and Cellular Biochemistry·Yan WuZhengguang Wang
Mar 28, 2019·BioMed Research International·Qie GuoFan-Bo Jing
Mar 10, 2019·BMC Cancer·Qi ChenWenlin Xu
Jun 21, 2018·Journal of Translational Medicine·Siao-Syun GuanShing-Hwa Liu
Mar 14, 2020·Journal of Experimental & Clinical Cancer Research : CR·Fang WangLiwu Fu
Jun 14, 2020·Oncology Research·Qie GuoMei-Xing Yan
Aug 15, 2019·Seminars in Cancer Biology·Stefania NobiliEnrico Mini
Jan 14, 2017·Oncology Research·Shoumiao LiYong Zhang