The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer.

Journal of Experimental & Clinical Cancer Research : CR
Wen-Qing HuYan Li

Abstract

To detect the expression of multidrug resistance molecules P-glycoprotein (P-gp), Lung resistnce protein (LRP) and Multidrug resistance-associated protein (MRP) and analyze the relationship between them and the clinico-pathological features. The expressions of P-gp, LRP and MRP in formalin-fixed paraffin-embedded tissue sections from 59 gastric cancer patients were determined by a labbelled Streptavidin-Peroxidase (SP) immunohistochemical technique, and the results were analyzed in correlation with clinicopathological data. None of these patients received chemotherapy prior to surgery. The positive rates of P-gp, LRP, MRP were 86.4%, 84.7% and 27.1%, respectively. The difference between the positive rate of P-gp and MRP was significant statistically, as well as the difference between the expression of MRP and LRP. No significant difference was observed between P-gp and LRP, but the positively correlation between the expression of P-gp and LRP had been found. No significant correlation between the expression of P-gp, LRP, MRP and the grade of differentiation were observed. The expression of P-gp was correlated with clinical stages positively (r = 0.742), but the difference with the expression of P-gp in different stages was not ...Continue Reading

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Citations

Nov 1, 2011·Journal of Experimental & Clinical Cancer Research : CR·Yun HeGuanghui Wei
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hua SuiQi Li
Oct 27, 2015·Molecular and Cellular Biochemistry·Yan WuZhengguang Wang
Mar 14, 2020·Journal of Experimental & Clinical Cancer Research : CR·Fang WangLiwu Fu
Jun 14, 2020·Oncology Research·Qie GuoMei-Xing Yan
Aug 15, 2019·Seminars in Cancer Biology·Stefania NobiliEnrico Mini

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Methods Mentioned

BETA
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Software Mentioned

SPSS

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