The expression and significance of the enhancer of zeste homolog 2 in lung adenocarcinoma

Oncology Reports
Yijing LvJidong Zhang

Abstract

Lung adenocarcinoma, with increased incidence in the world, exhibits poor prognosis and is usually resistant to conventional chemotherapy due to drug resistance. The enhancer of zeste homologue 2 (EZH2), a histone methyltransferase, plays a key role in tumorigenesis and cancer development through chromatin remodeling in various types of cancer. However, its potential role in lung adenocarcinoma has not been well defined. In this study, the expression of EZH2 was examined in lung adenocarcinoma tissues and cell lines. Most interestingly, EZH2 overexpression was detected in tumor tissue and significantly correlated with histological differentiation, pathological tumor-node-metastasis stage and smoking history, but not with gender or age. Furthermore, EZH2 overexpression was also detected in cisplatin-resistant cancer cells rather than cisplatin-sensitive cells. Short hairpin RNA targeted against EZH2 inhibited cell proliferation and migration, and led to G(2)/M cell cycle arrest and apoptosis in both cisplatin-resistant and cisplatin-sensitive cell lines. Moreover, EZH2 knockdown enhanced cisplatin sensitivity of cisplatin-resistant cells and reduced the expression levels of multidrug resistance-related protein 1. Our study sugge...Continue Reading

Citations

Jun 20, 2012·Cancer Metastasis Reviews·Francesco CreaRomano Danesi
Jul 21, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hirohito Yamaguchi, Mien-Chie Hung
Apr 2, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Scott M LangevinKarl T Kelsey
Nov 19, 2015·International Journal of Molecular Sciences·Mónica Martínez-FernándezJesús M Paramio
Jun 22, 2017·Scientific Reports·Steffen KiehlReinhard H Dammann
Aug 2, 2017·International Journal of Molecular Sciences·Zoe VenetiAristides G Eliopoulos
Oct 15, 2020·Clinical Epigenetics·Theodore VougiouklakisVassiliki Saloura

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