The expression levels and the differential expression of transforming growth factor-beta receptors in dermatofibroma and dermatofibrosarcoma protuberans

The British Journal of Dermatology
Masahide KuboKunihiko Tamaki

Abstract

Dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) are benign and intermediate malignant fibrotic dermal tumours, respectively. The contribution of transforming growth factor (TGF)-beta has been implicated in the progression of sclerosis in fibrotic diseases. To investigate the expression of TGF-beta receptors in these fibrotic tumours. We examined the expression levels of TGF-beta type I and type II receptors (TGFbeta-RI and TGFbeta-RII) in DF and DFSP using in situ hybridization and immunohistochemical analysis. We also examined the expression of TGF-beta1 and collagen type I using immunohistochemical analysis. We detected strong expression of TGFbeta-RI and TGFbeta-RII on epidermis and epidermal appendages, moderate expression in vascular endothelial cells, smooth muscle cells and neural tissues, and weak expression in fibroblasts in normal skin sections. The expression levels of TGFbeta-RI and TGFbeta-RII were elevated in the tissue sections of DF in comparison with normal dermal sections using in situ hybridization and immunohistochemical staining. Furthermore, the expression of TGFbeta-RI and TGFbeta-RII was strong in spindle-shaped cells around DF. The expression of TGFbeta-RI and TGFbeta-RII was decreased in...Continue Reading

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Citations

Apr 5, 2008·Journal of Dermatological Science·Nevena SkrozaCinzia Marchese
Aug 19, 2008·The Journal of Dermatology·Toru MoriYutaka Narisawa
Apr 16, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·J LiH Chen
Dec 25, 2012·Journal of the American Academy of Dermatology·David E KurlanderJeremy S Bordeaux
Mar 8, 2011·Journal of Autoimmunity·Kae TakagiHisashi Yamanaka
Oct 29, 2013·The American Journal of Dermatopathology·Kelly L WestPuja K Puri
Jan 30, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·T Yamamoto

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