The Expression of Androgen Receptor and Its Variants in Human Prostate Cancer Tissue according to Disease Status, and Its Prognostic Significance

The World Journal of Men's Health
Sung Woo ParkSik Yoon

Abstract

To evaluate changes in the expression of androgen receptor (AR) and its variants (ARVs) in human prostate cancer (PCa) tissues according to disease status, and its prognostic significance following radical prostatectomy (RP). A total of 282 PCa cases were evaluated, which included 252 localized PCa, 8 metastatic castration resistant prostate cancer (CRPC), and 22 benign prostatic hyperplasia (BPH) cases. Samples were collected from patients who underwent RP or transurethral resection and were stored in ethically approved tissue banks. Quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemistry were performed for AR and ARVs. Each tissue was confirmed as cancerous (greater than 80%) using hematoxylin and eosin staining. AR and ARVs expression was compared according to disease status. The biochemical recurrence free survival (BCRFS) rates in men with localized PCa was analyzed according to AR and ARV7 expression using the Kaplan-Meier curve. Only 58 of the 252 localized PCa were included in the analysis because of insufficient cancer tissue. AR and ARV7 mRNA expression was higher in the CRPC tissue than in the localized PCa tissue (p=0.025, p=0.002, respectively). In localized PCa tissue, high AR ...Continue Reading

References

May 25, 1995·The New England Journal of Medicine·M E TaplinS P Balk
Apr 7, 2006·Journal of Cellular Biochemistry·Zoran Culig, Georg Bartsch
Jul 21, 2010·The Journal of Clinical Investigation·Shihua SunStephen R Plymate
Jul 28, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sarah MinnerThorsten Schlomm
Sep 4, 2014·The New England Journal of Medicine·Emmanuel S AntonarakisJun Luo

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Citations

Mar 25, 2017·Chinese Journal of Integrative Medicine·Woong Jin BaeSae Woong Kim

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Methods Mentioned

BETA
biopsy
PCR
antisense oligonucleotides
DNA assay

Software Mentioned

Statistical Package for Social Sciences ( SPSS )
LAS
3000

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