The expression of Bcl-2 gene in human lung cancer

Zhongguo fei ai za zhi = Chinese journal of lung cancer
Y WangZ Yang


To explore the relationship between the Bcl-2 gene transcript expression and the oncogenesis , and development of lung cancer. The expression of Bcl-2 mRNA was detected in 31 human lung cancer tissues , para-cancer tissues , non-cancer tissues and 13 benign lesion tissues by Northern blot. (1) The expression level of the Bcl-2 mRNA in the cancer tissues was significantly higher than that in the non-cancer tissues and benign lesion tissues ( P < 0. 01) , but there was no significant difference among the cancer and para-cancer tissues ,non-cancer and benign lesion tissues , para-cancer ,non-cancer and benign lesion tissues either ( P > 0. 05). (2) The Bcl-2 expression in poor-differentiated lung cancers was significantly higher than that in moderate-well differentiated lung cancers. (3) No significant difference was observed in Bcl-2 expression in different histoclassification of the cancer and P-TNM stages of the cancer. There is an overexpression of Bcl-2 mRNA in lung cancer tissues , and it may be involved in the oncogenesis and development of lung cancer.

Related Concepts

Western Blotting
Malignant Neoplasms
Connective Tissue Cells
RNA, Messenger
Malignant Neoplasm of Lung
BCL2 gene
Tumor Tissue Sample
Protein Expression

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