The expression of BIRC5 is correlated with loss of specific chromosomal regions in breast carcinomas

Genes, Chromosomes & Cancer
R BoidotS Lizard-Nacol

Abstract

Expression of BIRC5 (survivin), a member of the inhibitor of apoptosis protein (IAP) family, is elevated in fetal tissues and in various human cancers. Mechanisms up-regulating BIRC5 in cancer are poorly understood. Here, we show that overexpression of BIRC5 induces a high proliferation level in MCF-7 breast tumor cells. In a population of 191 breast carcinomas, BIRC5 expression is not affected by BIRC5 promoter polymorphism at -31, or BIRC5 gene copy number. However, a significant correlation was found between expression of demethylase (dMTase) and expression of BIRC5. In addition, among 13 chromosomal regions tested for allelic loss [loss of heterozygosity (LOH)], two regions close to D3S1478 and D6S264 were related to BIRC5 expression. In tumors with LOH at D3S1478 and/or D6S264, BIRC5 expression was significantly increased. These regions have been suggested to harbor tumor suppressor genes and/or common fragile sites that may play a role in increasing genetic instability. These results suggest that genes located near D3S1478 and D6S264 might work by inhibiting, directly or indirectly, BIRC5 expression and thus their loss leads to its up-regulation. In addition, BIRC5 expression may induce breast tumor proliferation by promo...Continue Reading

References

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Citations

Jan 26, 2012·European Journal of Human Genetics : EJHG·Xiefeng WangYongping You
Feb 18, 2012·International Immunology·Ildikó UngváriCsaba Szalai
Sep 13, 2012·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Chunsen XuHirotaka Iwase
Aug 28, 2014·Breast Cancer Research and Treatment·Chi-Cheng HuangEric Y Chuang
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Moltira PromkanSubhas Chakrabarty
Jun 12, 2013·Experimental Gerontology·Hitoshi Suda
May 1, 2012·Ageing Research Reviews·Valerie Vanhooren, Claude Libert
Feb 10, 2012·Journal of Dental Research·C J WengS F Yang
Jul 16, 2014·Molecular Medicine Reports·Qing XuHongxia Zhu
May 16, 2020·British Journal of Haematology·Mohamad Zamani-AhmadmahmudiFatemeh Soltaninezhad
Nov 8, 2013·Molecular Biology Reports·Romain BoidotSarab Lizard-Nacol
Nov 24, 2016·BMC Cancer·Fatemeh KavehHiroko K Solvang
Apr 1, 2020·Indian Journal of Clinical Biochemistry : IJCB·Bita MoudiHamidreza Mahmoudzadeh-Sagheb

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