PMID: 16624125Apr 21, 2006Paper

The expression of capillary hypoxia-induced factor-alpha and pulmonary artery remodeling in chronic obstructive pulmonary disease

Zhonghua nei ke za zhi
Qi-fang LiPing Xu

Abstract

To observe the expression of hypoxia-inducible factor-alpha (HIF-1alpha, HIF-2alpha, HIF-3alpha) and pulmonary vascular remodeling in pulmonary arteries of patients with chronic obstructive pulmonary disease (COPD). Pulmonary specimens were obtained from patients undergoing lobectomy for lung cancer, of whom 12 had concurrent COPD and 10 without COPD. Pulmonary vascular remodeling was observed with optical microscope, and HIF-alpha mRNA and protein were detected by in situ hybridization and immunohistochemistry respectively. Vascular remodeling parameters (WT%, WA%) of COPD patients [(24 +/- 3)%, (48 +/- 6)%, respectively] were statistically different from those of the control subjects [(15 +/- 2)%, (39 +/- 4)%, respectively]. Relative quantification of mRNA and protein levels (absorbance, A) showed that HIF-1alpha in COPD group (0.172 +/- 0.011, 0.089 +/- 0.013, respectively) were statistically higher than those of the control subjects (0.103 +/- 0.010, 0.042 +/- 0.010, P < 0.01). Furthermore, they correlated positively with the parameters for vascular remodeling. The mRNA and protein levels of HIF-2alpha in COPD group (0.038 +/- 0.010, 0.077 +/- 0.010, respectively) were significantly lower than those of the control subjects ...Continue Reading

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