The Expression of Carbonic Anhydrase (CA) IX/XII and Lymph Node Metastasis in Early Breast Cancer

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Keun-Yong EomIn Ah Kim

Abstract

The aim of study was to test by immunohistochemical (IHC) staining whether carbonic anhydrase (CA) 9 and 12 have an effect on sentinel lymph node (SLN) metastasis in early breast cancer and to find clinicopathologic factors associated with SLN metastasis. Between June 2003 and June 2011, medical records of 470 patients diagnosed with breast cancer with pT1-2, pN0-2, and M0 were reviewed. Of these 470, 314 patients who underwent SLN biopsy±axillary dissection were subjects of this study. Using tissue microarray, IHC staining for CA9 and CA12 was performed. Clinicopathologic factors such as patient age, tumour size, lymphatic invasion, hormone receptor status, and the Ki-67 labeling index were analysed together. The mean age of all patients was 51.7 years. The mean number of harvested SLN was 3.62, and 212 patients (67.5%) had negative SLN. Lymphatic invasion, the Ki-67 labelling index of primary tumours, and CA9 staining of stromal cells, were independent risk factors for SLN metastasis in the multivariate analysis. In 33 patients (10.5%) without the three risk factors, no patient had SLN metastasis. In 80 patients without lymphatic invasion of primary tumours or CA9 staining of stromal cells, only four patients (5%) had positiv...Continue Reading

References

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Citations

May 18, 2016·Virchows Archiv : an International Journal of Pathology·Min-Sun JinHan Suk Ryu
Sep 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bo LeiDa Pang
Apr 11, 2020·Cancers·Khalid O AlfaroukStephan J Reshkin

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Methods Mentioned

BETA
dissection
biopsy

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