Abstract
The aim of study was to test by immunohistochemical (IHC) staining whether carbonic anhydrase (CA) 9 and 12 have an effect on sentinel lymph node (SLN) metastasis in early breast cancer and to find clinicopathologic factors associated with SLN metastasis. Between June 2003 and June 2011, medical records of 470 patients diagnosed with breast cancer with pT1-2, pN0-2, and M0 were reviewed. Of these 470, 314 patients who underwent SLN biopsy±axillary dissection were subjects of this study. Using tissue microarray, IHC staining for CA9 and CA12 was performed. Clinicopathologic factors such as patient age, tumour size, lymphatic invasion, hormone receptor status, and the Ki-67 labeling index were analysed together. The mean age of all patients was 51.7 years. The mean number of harvested SLN was 3.62, and 212 patients (67.5%) had negative SLN. Lymphatic invasion, the Ki-67 labelling index of primary tumours, and CA9 staining of stromal cells, were independent risk factors for SLN metastasis in the multivariate analysis. In 33 patients (10.5%) without the three risk factors, no patient had SLN metastasis. In 80 patients without lymphatic invasion of primary tumours or CA9 staining of stromal cells, only four patients (5%) had positiv...Continue Reading
References
Mar 10, 2001·The American Journal of Pathology·C C WykoffA L Harris
Jun 16, 2001·Annals of Surgical Oncology·D R BreninD Kinne
Oct 24, 2002·The New England Journal of Medicine·Umberto VeronesiEttore Marubini
Nov 1, 2002·Breast Cancer Research and Treatment·Arnim A BaderAugustinus H Tulusan
Apr 3, 2003·British Journal of Cancer·P H WatsonA L Harris
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Apr 25, 2007·British Journal of Cancer·E de AzambujaM Paesmans
Oct 25, 2007·Cellular and Molecular Life Sciences : CMLS·K LundgrenG Landberg
Nov 21, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M Christiane Brahimi-HornJacques Pouysségur
May 3, 2008·Cancer Research·Daniel H BarnettBenita S Katzenellenbogen
Nov 8, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Manuela Milani, Adrian L Harris
Apr 7, 2010·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jong Hoon LeeHoon Kyo Kim
May 4, 2010·European Journal of Cell Biology·Ming-Ju HsiehYih-Shou Hsieh
Nov 3, 2010·Journal of Oncology Practice·M Elizabeth H HammondSarah Temin
Mar 3, 2011·Journal of Cell Science·Hye-Jin ShinJoo-Young Kim
Mar 1, 2012·Oral Oncology·Nigel T BrocktonJoseph C Dort
Jan 30, 2013·Journal of Cancer Research and Clinical Oncology·Dina SchützeVolkmar Müller
Feb 23, 2013·Annals of Surgical Oncology·Tomoharu SugieMasakazu Toi
May 10, 2013·Cell Cycle·Tania FiaschiPaola Chiarugi
Jun 5, 2014·BMC Cancer·Naoki AomatsuKosei Hirakawa
Jun 22, 2014·Annals of Surgical Oncology·Stacy UgrasMonica Morrow
Citations
May 18, 2016·Virchows Archiv : an International Journal of Pathology·Min-Sun JinHan Suk Ryu
Sep 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bo LeiDa Pang
Jan 26, 2020·International Journal of Molecular Sciences·Daniele VergaraMichele Maffia
Jun 11, 2020·Molecular Oncology·Shaoquan ZhengXiaoming Xie
Sep 8, 2020·Biology of the Cell·Simonas Daunys, Vilma Petrikaitė
Apr 11, 2020·Cancers·Khalid O AlfaroukStephan J Reshkin
May 25, 2016·Cancer Research·Manjulata SinghShilpa Sant