The expression of collagen I and XII mRNAs in Porphyromonas gingivalis-induced periodontitis in rats: the effect of doxycycline and chemically modified tetracycline

Journal of Periodontology
N Y KarimbuxI Nishimura

Abstract

Tissue remodeling is a dynamic state in which a balance is achieved between the proteolytic breakdown and synthesis of the extracellular matrix. Type I collagen is a major component of the gingival connective tissue (GCT) and the periodontal ligament (PDL) throughout development, while type XII collagen has been found in the mature forms of these tissues. The purpose of this study was to investigate the effects of periodontitis on the expression of type I and XII collagen and subsequently to investigate the effects of doxycycline (DOXY) and chemically modified non-antimicrobial tetracycline (CMT-1) on the expression of these molecules in this model. Adult barrier-raised male Sprague-Dawley rats were inoculated with Porphyromonas gingivalis obtained from humans to create the experimental periodontitis. The animals with the P. gingivalis-induced periodontitis were then split into the following groups: Group A served as infected untreated controls (PGI group); group B was treated with doxycycline (DOXY group); and group C was treated with chemically modified tetracycline-1 (CMT-1 group). Group D contained uninfected animals that served as uninfected controls (NIC group). The expression of type I and XII collagen mRNAs was examined...Continue Reading

References

Jan 1, 1976·Archives of Oral Biology·H Birkedal-HansenH M Fullmer
Jan 15, 1978·The Biochemical Journal·H F LimebackD M Brunette
Jul 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·J N CloreR F Diegelmann
May 1, 1991·The Journal of Cell Biology·D R KeeneR E Burgeson
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M K GordonB R Olsen
May 1, 1982·Journal of Periodontal Research·P B RobertsonS C Holt
Aug 1, 1980·Journal of Periodontology·P Christner
Nov 1, 1981·Journal of Periodontal Research·D W PettigrewD M Brunette
Mar 1, 1983·Journal of Periodontal Research·H M WangJ Sodek
Jan 1, 1984·Journal of Clinical Periodontology·S S SocranskyJ Lindhe
Feb 1, 1995·Journal of Clinical Periodontology·L M GolubY T Konttinen
Jun 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C Q Lin, M J Bissell
May 1, 1993·Infection·Y LermanY L Danon
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Birkedal-HansenJ A Engler

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Citations

Mar 19, 2014·PloS One·Mercedes F RiveraLakshmyya Kesavalu
Jun 29, 2013·Journal of Periodontology·Rafael Scaf de MolonJoni Augusto Cirelli
Apr 25, 2012·Indian Journal of Pharmacology·Rupali Agnihotri, Sumit Gaur
Nov 29, 2012·Journal of Investigative and Clinical Dentistry·Rafael Scaf de MolonJoni Augusto Cirelli
Sep 29, 2015·Clinical Oral Investigations·Rafael Scaf de MolonJoni Augusto Cirelli
Sep 2, 2006·Journal of Periodontology·Gonca Cayir KelesHulya Koprulu
Nov 9, 2019·Clinical Oral Implants Research·Jingqing SunMeike Stiesch
Jul 8, 2008·Informatics for Health & Social Care·Umut Burcu TasaAyca Unluer

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