The expression of common fragile sites and genetic predisposition to squamous cell lung cancers

Cancer Genetics and Cytogenetics
U EgeliN Ozyardímcí

Abstract

The chromosomal aberration rates (including gaps and breaks) and expression frequency of fragile sites were determined in peripheral blood lymphocytes cultured with TC 199 medium from 8 patients with squamous cell lung cancer, 10 of their first-degree relatives, and 12 healthy control subjects. As a result of cytogenetic evaluation, both the chromosomal aberration rates and expression frequencies of common fragile sites observed in patients and their relatives were significantly higher than those in healthy control subjects. Our results showed that common fragile sites might be unstable factors in the human genome, and their expression might be affected by some genetic and environmental factors. As a result of this they might play an important role in genetic predisposition to lung cancer. The high expression of fra(3)(p14) in patients and their relatives may be a valid marker for genetic predisposition to lung cancer.

References

Nov 1, 1990·Cancer Genetics and Cytogenetics·P VernoleB Nicoletti
Mar 1, 1988·Cancer Genetics and Cytogenetics·F Hecht, A A Sandberg
Mar 1, 1988·Cancer Genetics and Cytogenetics·M M Le Beau
Feb 1, 1986·Journal of the National Cancer Institute·W L OoiH Rothschild
Jan 1, 1987·Cytogenetics and Cell Genetics·G R Sutherland, J F Mattei
Dec 7, 1984·Science·J J Yunis, A L Soreng
Oct 1, 1984·Cancer Genetics and Cytogenetics·F Hecht, T W Glover
Jan 24, 1980·Nature·J M Hopkins, H J Evans
Jun 1, 1993·Cancer Genetics and Cytogenetics·C ArdisiaE Donti
Oct 29, 2004·Nature Reviews. Cancer·Albert de la Chapelle

❮ Previous
Next ❯

Citations

Jan 7, 2000·Journal of Cellular Physiology·S R SoltaninassabM L Freeman
Sep 18, 2009·Cellular and Molecular Neurobiology·Gulsah CecenerKaya Aksoy
Apr 12, 2002·Cancer Genetics and Cytogenetics·Güvem GümüşIşik Bökesoy
Jun 27, 2000·Cancer Genetics and Cytogenetics·B TuncaA Kizil
Jan 5, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·M KaradağO Gözü
Aug 26, 1998·The Journal of Veterinary Medical Science·K KuboY Takamori
May 15, 2002·Genes, Chromosomes & Cancer·Constance K SteinBonnie S Glisson
Nov 15, 2002·International Journal of Cancer. Journal International Du Cancer·Yong ZhuXifeng Wu
Apr 12, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Berrin TuncaIlker Ercan
Oct 24, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·B TuncaR Bilaloglu
Nov 14, 2000·Teratogenesis, Carcinogenesis, and Mutagenesis·U EgeliR Bilaloglu
Oct 7, 1998·International Journal of Cancer. Journal International Du Cancer·X WuM R Spitz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.