PMID: 8967785Mar 1, 1996Paper

The expression of cytokines by an established basal cell carcinoma cell line (BCC-1/KMC) compared with cultured normal keratinocytes

Archives of Dermatological Research
H T YenH S Yu

Abstract

A basal cell carcinoma (BCC) cell line (BCC-1/KMC) has recently been successfully established from a patient. The production of interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-6 and IL-8 was assessed in comparison with that of cultured normal keratinocytes. The mRNA expression of these cytokines was measured by a reverse transcriptase-polymerase chain reaction (RT-PCR) method and the protein production by an ELISA. The cultured BCC cells spontaneously secreted more IL-6 and IL-8 but less IL-1 than the keratinocytes after culture for 24 h at 37 degrees C. It is suggested that the increased expression of IL-6 and IL-8 may indicate the transformation of normal keratinocytes to locally aggressive BCC.

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Citations

Jul 11, 2006·Archives of Dermatological Research·T GambichlerA Kreuter
Mar 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhenzhong ZhangBengt Lindholm
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Tak-Wah WongYin-Ching Chuang
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Apr 30, 2010·The British Journal of Dermatology·S-W HuangJ-J Shieh
Jan 21, 2006·Journal of Dermatological Science·Jia-You FangYen-Ling Huang
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Jan 12, 2019·Frontiers in Medicine·Jennifer A BridgeJeffrey A Bluestone
Apr 18, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Weiguo LiuAllan R Oseroff

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