The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells

Cancer Science
Hiroaki KajiyamaFumitaka Kikkawa

Abstract

Dipeptidyl peptidase IV (DPPIV/CD26) is a multifunctional cell surface aminopeptidase that is widely expressed in different cell types. Recent studies have suggested that DPPIV plays an important role in tumor progression in several human malignancies. In the current study, we investigated the role of DPPIV in paclitaxel resistance in epithelial ovarian carcinoma (EOC) cells. We first examined the correlation between expression levels of DPPIV and sensitivity to paclitaxel in various EOC cell lines. Subsequently, to clarify the cellular functions of DPPIV, we investigated the role of this molecule in the sensitivity of EOC to paclitaxel in vitro and in vivo using stably DPPIV-transfected EOC cells. We identified a positive correlation between DPPIV expression and paclitaxel sensitivity in various EOC cell lines. In addition, we observed a significant increase in the paclitaxel sensitivity of DPPIV-overexpressing EOC cells. Furthermore, no apparent alteration in paclitaxel sensitivity was noted by the addition of a specific inhibitor of DPPIV activity in DPPIV-transfected or natively DPPIV-overexpressing EOC cells. In a subcutaneous murine model treated with paclitaxel, on Day 39, the tumor size of the DPPIV-transfected cell-ino...Continue Reading

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Aug 21, 2012·World Journal of Clinical Oncology·Shailendra Kapoor
Jan 27, 2012·Stem Cell Reviews and Reports·Cristóbal Aguilar-GallardoCarlos Simón
Mar 5, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Aline BeckenkampAndréia Buffon
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Jun 28, 2012·International Journal of Oncology·Claire H Wilson, Catherine A Abbott
Nov 24, 2018·Virchows Archiv : an International Journal of Pathology·Marta BrunettiBen Davidson

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