PMID: 25744843Mar 7, 2015Paper

The expression of fibroblast activation protein-α in primary breast cancer is associated with poor prognosis

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Hai-Ming YuShun-Chang Jiao

Abstract

To evaluate the prognostic value of fibroblast activation protein-α (FAP-α) expression in primary lesions of breast cancer patients and the relationship with the clinicopathologic features. Paraffin sections and clinical data were retrospectively collected from 130 stage I-III breast cancer patients who had underwent surgery at the Chinese PLA General Hospital from January 1st, 2000 to December 31st, 2002. Immunohistochemistry was used to assess FAP-α expression in primary lesions of breast cancer to evaluate the associations of FAP-α expression with transforming growth factor-β1 (TGF-β1) expression in breast cancer and patients' clinicopathologic characteristics and prognosis. FAP-α was seen in cytoplasm of tumor cells and interstitial fibroblasts. Density of interstitial FAP-α-positive fibroblasts was positively correlated with the staining density of interstitial TGF-β-positive cells. Intensity of CTLA-4 expression in tumor cells was positively correlated with TGF-β1 expression in tumor cells. In patients whose lesions were negative for both estrogen and progesterone receptors, density of interstitial FAP-α-positive fibroblasts was an independent adverse prognostic factor for disease-free survival (DFS) and overall survival ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Hai-Ming YuShun-Chang Jiao
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Ying LiJun-Lan Yang
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Hai-Ming YuJian-Dong Wang
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Wenxiu XieJunhao You
International Journal of Clinical and Experimental Medicine
Liying GuoTing Liang
© 2022 Meta ULC. All rights reserved