The expression of Fos-labeled spinal neurons in response to colorectal distension is enhanced after chronic spinal cord transection in the rat

Neuroscience
L M LandrumR W Blair

Abstract

The present study used Fos-like immunoreactivity to examine neuronal activation in response to colorectal distension in rats at 1 day or 30 days following spinal cord transection or sham transection. Fifty-five Wistar rats were anesthetized and an incision was made to expose the T(5) spinal segment. The dura was reflected away in all rats and a complete transection at the rostral end of the T(5) segment was given to the lesioned group. At 1 day (acute) or 30 days (chronic) post-surgery, conscious rats were subjected to a 2 h period of intermittent colorectal distension. Rats were perfused and spinal segments L(5)-S(2) were removed and processed for Fos-like immunoreactivity. Spinal cord transection alone had no effect on Fos-labeling in either acute or chronic rats. In acute rats, colorectal distension produced significant increases in Fos-labeling in the superficial and deep dorsal horn regions. In chronic rats, colorectal distension produced a three-fold increase in Fos-labeled neurons that was manifest throughout all laminar regions. These results indicate that the number of neurons expressing Fos in response to colorectal distension is much greater after a chronic spinal cord transection than after an acute transection. Sin...Continue Reading

References

Jan 31, 1976·Lancet·P Sleight
Apr 26, 2006·Spinal Cord·F Biering-SørensenK Klinge

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Citations

May 3, 2007·Expert Opinion on Pharmacotherapy·Jay KhastgirPaul Abrams
May 29, 2007·Neuroscience Research·Daniel A CastellanosJacqueline Sagen
Aug 5, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K BielefeldtB M Davis
Nov 2, 2017·Neural Regeneration Research·Hisham Sharif, Shaoping Hou

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