The expression of IGF-I and myostatin mRNAs in skeletal muscle of hypophysectomized and underfed rats during postnatal growth

Acta Physiologica
Akihiko YamaguchiT Hirai

Abstract

To determine the roles of myostatin and insulin-like growth factor-I (IGF-I) during postnatal growth, we examined IGF-I and myostatin mRNA expression in the skeletal muscles of hypophysectomized and underfed rats during postnatal growth. Five-week-old rats were divided into four groups: freely fed control, moderately underfed, severely underfed and hypophysectomized. Four weeks later, blood and muscle samples were gathered to determine serum IGF-I, myosin heavy chain (MHC) isoforms, IGF-I Ea, IGF-I Eb and myostatin mRNA. The weights of soleus, plantaris and masseter muscles were decreased in underfed and hypophysectomized rats. Hypophysectomy resulted in significant increases of type I MHC at the expense of type IIx in plantaris muscle and of neonatal MHC at the expense of types IIx and IIb in masseter muscle. Serum IGF-I was decreased by underfeeding and hypophysectomy. Plantaris muscle IGF-I Ea mRNA in underfed and hypophysectomized rats was significantly lower than in normal controls. Plantaris muscle IGF-I Eb mRNA in underfed rats was significantly lower than in normal controls. Masseter muscle IGF-I Eb mRNA in severely underfed rats was significantly lower than in normal control and hypophysectomized rats. Soleus muscle my...Continue Reading

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Citations

Aug 31, 2006·Pflügers Archiv : European journal of physiology·Akihiko YamaguchiToshihiro Hirai
Dec 3, 2008·The Journal of Physiology·Jenny M OldhamChristopher D McMahon
Sep 16, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Na Na KimCheol Young Choi
Aug 3, 2010·Journal of Cellular Biochemistry·Ira J SmithPer-Olof Hasselgren
Mar 13, 2009·Organogenesis·Charlotte A Maltin
Apr 15, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Iban SeiliezJean-Charles Gabillard
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui FanYong Li

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