Abstract
The role of neuroinflammation in mesial temporal lobe epilepsy (MTLE), and how it relates to drug resistance, remains unclear. Expression levels of the inflammatory enzymes cyclooxygenase (COX)-1 and COX-2 have been found to be increased in animal models of epilepsy. Knowing the cellular expression of COX-1 and COX-2 is the key to understanding their functional role; however, only 3 studies have investigated COX-2 expression in epilepsy in humans, and there are no reports on COX-1. In addition, previous studies have shown that certain inflammatory proteins up-regulate ATP binding cassette (ABC) transporter expression (thought to be responsible for drug resistance), but this relationship remains unclear in human tissue. This study sought to measure the expression of COX-1, COX-2, and translocator protein 18 kDa (TSPO, an inflammation biomarker acting as a positive control), as well as ABC transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), in brain tissue samples from people with drug-resistant MTLE. Formalin-fixed paraffin-embedded surgical brain tissue was obtained from 33 patients with drug-resistant MTLE. Multiplex immunofluorescence was used to quantify the expression and distribution of COX-1, C...Continue Reading
References
Dec 22, 1999·Neurology·R B BanatiJ S Duncan
Dec 10, 2002·Neurochemistry International·Paul DesjardinsRoger F Butterworth
Nov 26, 2003·Epilepsia·Sanjay M SisodiyaMaria Thom
Apr 23, 2004·Epilepsia·Eleonora AronicaFiliz Ozbas-Gerçerer
Jun 11, 2005·Epilepsia·Eleonora AronicaDirk Troost
Jul 14, 2005·Progress in Neurobiology·Wolfgang Löscher, Heidrun Potschka
Dec 20, 2005·Epilepsy Research·Hisashi KubotaKarl Frei
Jun 21, 2006·Journal of Cardiovascular Pharmacology·Jan SteffelFelix C Tanner
Jul 11, 2006·Trends in Pharmacological Sciences·Vassilios PapadopoulosMoshe Gavish
Dec 21, 2007·Molecular Pharmacology·Björn BauerHeidrun Potschka
Feb 3, 2009·Epilepsy Research·L HoltmanJ A Gorter
Sep 30, 2009·Neuropharmacology·Erwin A van VlietHeidrun Potschka
Sep 28, 2010·Biochimie·Saba Aïd, Francesca Bosetti
Dec 2, 2010·Nature Reviews. Drug Discovery·Rainer RupprechtMichael Schumacher
Sep 9, 2011·The New England Journal of Medicine·Patrick KwanMartin J Brodie
Oct 12, 2011·Experimental Neurology·Annamaria VezzaniQuentin J Pittman
Jan 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jussi HirvonenWilliam H Theodore
Mar 27, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Milan FialaMartin Weinand
Jul 4, 2012·Brain : a Journal of Neurology·Joan Y W LiuSanjay M Sisodiya
Nov 10, 2012·EJNMMI Research·Stefanie DedeurwaerdereMarie-Claude Grégoire
May 23, 2013·Epilepsia·Ingmar BlümckeRoberto Spreafico
Aug 13, 2013·PloS One·Denise HarhausenAndreas Wunder
Apr 22, 2015·Molecular Pharmaceutics·Josephine D SalvamoserHeidrun Potschka
May 23, 2015·The International Journal of Neuroscience·Guang-Xin WangYan-Hui Ma
Jun 9, 2015·JAMA Neurology·Leah D GershenWilliam H Theodore
Sep 22, 2015·Neurobiology of Disease·Halima AmhaoulStefanie Dedeurwaerdere
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Mariko L BennettBen A Barres
Aug 5, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Pavitra KannanJan Mulder
Mar 9, 2017·Seizure : the Journal of the British Epilepsy Association·Aparna Banerjee DixitP Sarat Chandra
Citations
May 16, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Brad A HobsonPamela J Lein
Nov 2, 2019·Journal of Neuroinflammation·Chitra RawatRitushree Kukreti
Oct 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anika M S HartzBjoern Bauer
May 15, 2020·Aging·Xiaodong CaiZhong Li
Jul 18, 2019·Frontiers in Neurology·Dominik KobylarekWojciech Kozubski
Feb 15, 2020·Scientific Reports·Chitra RawatRitushree Kukreti
Apr 8, 2020·Frontiers in Behavioral Neuroscience·Jerónimo AuzmendiAlberto Lazarowski
Jun 17, 2020·Pharmacological Reviews·Wolfgang LöscherAnnamaria Vezzani
Jan 13, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Erik NutmaBenjamin B Tournier
Sep 9, 2019·Life Sciences·Seyed Abbas MirzaeiFatemeh Elahian
Feb 21, 2021·Acta Neuropathologica·Emma GerritsErik W G M Boddeke
Jun 3, 2021·Brain Sciences·Elena D BazhanovaAnastasia V Litovchenko
Sep 7, 2021·Epilepsia·Julia BohosovaStefania Aulicka
Sep 10, 2021·Frontiers in Pharmacology·Meng FuZhiping Li
Sep 30, 2021·Cellular and Molecular Life Sciences : CMLS·Samiksha KukalRitushree Kukreti
Sep 25, 2021·Epilepsia Open·Marta Vázquez, Pietro Fagiolino