PMID: 8953518Nov 1, 1996Paper

The expression of interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor type I mRNA during preimplantation mouse development

Journal of Reproductive Immunology
P Takacs, S Kauma

Abstract

Interleukin-1 (IL-1) plays an important role in implantation of the early embryo since blockade of the IL-1 receptor prevents implantation in the mouse. Whether IL-1 blockade during implantation has a direct effect on the embryo or only the uterus is unknown since reliable data are not available concerning the expression of IL-1 or IL-1 receptor on the preimplantation embryo. Because of the significant role for IL-1 in implantation, we investigated the potential for an embryonic-maternal IL-1 signaling mechanism during mouse preimplantation embryo development. Reverse transcriptase-polymerase chain reaction (RT-PCR) was performed for IL-1 alpha, IL-1 beta and IL-1 receptor type I (IL-1R) on mRNA isolated from mouse preimplantation embryos and uteri collected between the 2-cell to blastocyst stage. Preimplantation embryos have the capability to produce IL-1 beta after the 4-cell stage of development since IL-1 beta mRNA was detected from the 4-cell to blastocyst stage but not at the 2-cell stage. Unlike IL-1 beta, IL-1 alpha was not expressed in preimplantation embryos. It is unlikely that IL-1 has a direct effect on the preimplantation embryo since IL-1R mRNA was not expressed in preimplantation embryos. In contrast, IL-1 could...Continue Reading

Citations

Aug 2, 2008·Molecular Reproduction and Development·Yin-Lau LeeWilliam S B Yeung
Mar 9, 2002·American Journal of Reproductive Immunology : AJRI·Sayantani BasakChandana Das
May 1, 2004·The Journal of Reproduction and Development·Kazuhiko ImakawaRonald K Christenson
Oct 27, 2017·Proceedings. Biological Sciences·Victoria L HansenRobert D Miller
Aug 28, 2019·Journal of Cellular Biochemistry·Yangyang PanSijiu Yu
May 5, 2012·Reproductive Sciences·Xiu-Hong ZhangZeng-Ming Yang
Nov 27, 2015·Biological Reviews of the Cambridge Philosophical Society·Eline WydoogheAnn Van Soom
Dec 14, 2018·Experimental and Therapeutic Medicine·Hui WangLi Sheng
Aug 3, 2006·Mediators of Inflammation·Athip Nilkaeo, Suthinee Bhuvanath
Jun 22, 2018·Journal of Animal Science and Biotechnology·Hakhyun KaJisoo Han
Dec 27, 2015·American Journal of Reproductive Immunology : AJRI·Polani B SeshagiriPathak Madhulika
Dec 26, 2001·Archives of Medical Research·L Díaz-Cueto, G L Gerton
Jul 26, 2002·Fertility and Sterility·Anette LindhardSteen Sørensen
Dec 14, 2011·Journal of Proteome Research·Marta MuñozEnrique Gómez

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