The expression of lysozyme in multiple myeloma

Pathology, Research and Practice
L al SafadiH E Schaefer

Abstract

Lysozyme, a hitherto myelomonocytic marker, has been previously reported as being raised in the sera of some myeloma patients. This fact, and the sporadical observation of a positive immunohistochemical lysozyme staining seen in some myelomas, prompted us to systematically search for an expression of lysozyme in both neoplastic and reactive plasma cells. A total of 74 paraffin-embedded, formalin-fixed, EDTA-decalcified core biopsies of newly diagnosed cases of plasmacytoma were immunohistochemically investigated for lysozyme expression by a modified avidin-biotin immunoperoxidase technique. The myelomas were subclassified according to their nuclear maturity into poorly differentiated plasmacytoma (PDP) (30 cases), moderately differentiated plasmacytoma (MDP) (24 cases), and well differentiated plasmacytoma (WDP) (20 cases). An unexpected lysozyme positivity was seen in 16/74 cases, and was most prevalent in 10/30 cases of PDP. No correlation has been detected between either lysozyme and kappa or lambda light chain expression, or an abnormal activity of chloroacetate esterase sometimes seen in myeloma. Since lysozyme has not been found in normal plasma cells or reactive plasmacytosis, the expression of this antigen in myeloma re...Continue Reading

References

Sep 1, 1977·Clinical Immunology and Immunopathology·J S GreenbergerD S Rosenthal
Feb 1, 1975·Journal of Clinical Pathology·D Y Mason, C R Taylor
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·C Fellbaum, M L Hansmann
Apr 1, 1987·British Journal of Haematology·N C ZoumbosK Kapatais-Zoumbos
Apr 30, 1987·The New England Journal of Medicine·R E SobolD A Nelson
Jan 1, 1973·Journal of Clinical Pathology·D Catovsky, D A Galton
May 1, 1974·The Journal of Experimental Medicine·S GordonZ A Cohn
Feb 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R S BriggsS C Finch
May 1, 1983·British Journal of Haematology·G J MuftiC Race

❮ Previous
Next ❯

Citations

Sep 7, 2007·Veterinary Clinical Pathology·Jennifer H YearleyGregg A Dean
Sep 25, 2001·Blood·N V SmadjaUNKNOWN Groupe Français de Cytogénétique Hématologique
Apr 26, 2002·British Journal of Haematology·Christine J HarrisonKim H Orchard
Dec 12, 2003·European Journal of Haematology·Alejandra CottliarIrma Slavutsky
Mar 22, 2003·British Journal of Haematology·Christine J HarrisonKim H Orchard
Nov 25, 2003·Archives of Pathology & Laboratory Medicine·Ilene B Bayer-GarnerBruce R Smoller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.