The expression of mannose receptors in skin fibroblast and their involvement in Leishmania (L.) amazonensis invasion

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Renata C HespanholSuzana Côrte-Real


Leishmania are protozoa that invade mononuclear phagocytes with the involvement of different ligand-receptor systems, including mannose receptors. Until now, scant data are available concerning the mechanisms that govern the infection of Leishmania in other host cell types such as fibroblasts. Our aim was to analyze the expression of mannose receptors in primary cultures of skin fibroblasts (SF) further characterizing their role during the invasion of promastigotes of Leishmania (L.) amazonensis. Both fluorescent, light, and electron microscopy assays revealed that SF have mannose receptors since they bound and internalized mannosylated ligands in addition to being positively labeled by fuc-BSA-FITC probes. d-mannose competition assays revealed the participation of mannose receptors during the parasite association with SF presenting upregulated receptor expression during the initial steps of the infection. After longer periods of Leishmania:fibroblasts contact, the modulation noted in the host mannose receptors was reverted concomitantly to the infection control, suggesting that the parasites were required for the alteration maintenance and providing evidences that the SF may display microbicidal mechanisms to control the Leish...Continue Reading


Apr 1, 1990·American Journal of Respiratory Cell and Molecular Biology·P D Stahl
Feb 1, 1990·Journal of Leukocyte Biology·J Mauël
Oct 1, 1989·Immunology Today·D G Russell, P Talamas-Rohana
Feb 1, 1988·Experimental Cell Research·R Goldman
Mar 1, 1988·European Journal of Immunology·F S RizviA Capron
Jan 1, 1988·Journal of Cell Science. Supplement·R A Ezekowitz, P D Stahl
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T E WilemanP D Stahl
Jul 1, 1985·The Journal of Experimental Medicine·J M BlackwellS Gordon
Sep 1, 1974·Annals of Tropical Medicine and Parasitology·D H Lewis
Feb 1, 1983·Annals of Tropical Medicine and Parasitology·J P DedetL P da Silva
Jan 1, 1995·Infection and Immunity·M KelleherE Handman
Aug 1, 1994·Archives of Biochemistry and Biophysics·V L ShepherdS Vick
Sep 14, 1994·Journal of Immunological Methods·Y LombardP Poindron
Aug 1, 1993·The Journal of Experimental Medicine·C Reis e SousaJ M Austyn
Feb 1, 1993·Current Opinion in Immunology·K Sastry, R A Ezekowitz
Feb 1, 1996·European Journal of Immunology·A AvraméasP Midoux
Jul 1, 1996·Veterinary Pathology·J Hervás RodríguezJ C Gómez-Villamandos
Aug 15, 1997·Archives of Biochemistry and Biophysics·V L ShepherdR Abdolrasulnia
Jan 8, 1998·Proceedings of the Society for Experimental Biology and Medicine·M P GeldermanN Moguilevsky
Nov 27, 1999·International Journal for Parasitology·A L BanũlsM Tibayrenc
Apr 12, 2000·Microbes and Infection·S A LinehanS Gordon
Sep 7, 2001·Annual Review of Microbiology·D Sacks, S Kamhawi
Sep 7, 2001·Nature·G D Brown, S Gordon
Feb 28, 2002·Current Pharmaceutical Design·M A Vannier-SantosW de Souza
Mar 9, 2002·Science·Sena J LeeMichel C Nussenzweig
Mar 14, 2002·Experimental and Molecular Pathology·Anna C Cunningham
Sep 12, 2002·Biochimica Et Biophysica Acta·Lucy East, Clare M Isacke
Oct 16, 2002·Trends in Parasitology·Emanuela Handman, Denise V R Bullen
Feb 11, 2003·Cell Structure and Function·Maria de Nazaré Correia SoeiroMaria de Nazareth Leal Meirelles

❮ Previous
Next ❯


Mar 15, 2014·Memórias do Instituto Oswaldo Cruz·Roger Magno Macedo-SilvaSuzana Côrte-Real
Mar 20, 2013·BioMed Research International·Alicia Vázquez-MendozaMiriam Rodriguez-Sosa
Aug 21, 2009·Journal of the Peripheral Nervous System : JPNS·Wagner Baetas-da-CruzLeny A Cavalcante
Oct 10, 2013·Journal of Neuroscience Research·Litia A CarvalhoLeny A Cavalcante
Jan 23, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Wagner Baetas-da-CruzLeny A Cavalcante
Dec 18, 2018·Frontiers in Microbiology·Sanjay VarikutiAbhay R Satoskar
Apr 5, 2008·Parasitology Research·Dilvani O SantosHelena C Castro
Feb 10, 2019·BMC Microbiology·Emilie GiraudEvie Melanitou
Aug 16, 2006·The Journal of Membrane Biology·Fabiana R SantosPietro Ciancaglini
Feb 9, 2010·Memórias do Instituto Oswaldo Cruz·Leticia CoutinhoMaria de Nazaré Correia Soeiro
Sep 27, 2018·Chemistry, an Asian Journal·Jing HuJian Yin

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.