The expression of mannose receptors in skin fibroblast and their involvement in Leishmania (L.) amazonensis invasion

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Renata C HespanholSuzana Côrte-Real

Abstract

Leishmania are protozoa that invade mononuclear phagocytes with the involvement of different ligand-receptor systems, including mannose receptors. Until now, scant data are available concerning the mechanisms that govern the infection of Leishmania in other host cell types such as fibroblasts. Our aim was to analyze the expression of mannose receptors in primary cultures of skin fibroblasts (SF) further characterizing their role during the invasion of promastigotes of Leishmania (L.) amazonensis. Both fluorescent, light, and electron microscopy assays revealed that SF have mannose receptors since they bound and internalized mannosylated ligands in addition to being positively labeled by fuc-BSA-FITC probes. d-mannose competition assays revealed the participation of mannose receptors during the parasite association with SF presenting upregulated receptor expression during the initial steps of the infection. After longer periods of Leishmania:fibroblasts contact, the modulation noted in the host mannose receptors was reverted concomitantly to the infection control, suggesting that the parasites were required for the alteration maintenance and providing evidences that the SF may display microbicidal mechanisms to control the Leish...Continue Reading

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Citations

Mar 15, 2014·Memórias do Instituto Oswaldo Cruz·Roger Magno Macedo-SilvaSuzana Côrte-Real
Mar 20, 2013·BioMed Research International·Alicia Vázquez-MendozaMiriam Rodriguez-Sosa
Aug 21, 2009·Journal of the Peripheral Nervous System : JPNS·Wagner Baetas-da-CruzLeny A Cavalcante
Oct 10, 2013·Journal of Neuroscience Research·Litia A CarvalhoLeny A Cavalcante
Jan 23, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Wagner Baetas-da-CruzLeny A Cavalcante
Dec 18, 2018·Frontiers in Microbiology·Sanjay VarikutiAbhay R Satoskar
Apr 5, 2008·Parasitology Research·Dilvani O SantosHelena C Castro
Feb 10, 2019·BMC Microbiology·Emilie GiraudEvie Melanitou
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Feb 9, 2010·Memórias do Instituto Oswaldo Cruz·Leticia CoutinhoMaria de Nazaré Correia Soeiro
Sep 27, 2018·Chemistry, an Asian Journal·Jing HuJian Yin

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