PMID: 25743802Mar 7, 2015Paper

The expression of MRTF-A and AQP1 play important roles in the pathological vascular remodeling

Asian Pacific Journal of Cancer Prevention : APJCP
Yong Jiang

Abstract

Objective Myocardin-related transcription factor (MRTF)-A is a Rho signaling-responsive co-activator of serum response factor (SRF). The purpose of this study is to investigate the role of MRTF-A and AQP1 (aquaporin 1) in pathological vascular remodeling. MRTF-A, AQP1 and neointima expression was detected both in the wire injured femoral arteries of wild-type mice and the atherosclerotic aortic tissues of ApoE-/- mice. Expression of ICAM-1, matrix metallopeptidase 9 (MMP-9) and integrin β1 were also assayed. The intercourse relationship between the molecules were investigated by interfering RNA and inhibitor assay. MRTF-A and AQP1 expression were significantly higher in the wire injured femoral arteries of wild-type mice and in the atherosclerotic aortic tissues of ApoE-/- mice than in healthy control tissues. Both in wire-injured femoral arteries in MRTF-A knockout (Mkl1-/-) mice and atherosclerotic lesions in Mkl1-/-; ApoE-/- mice, neointima formation were significantly attenuated and the expression of AQP1 were significantly decreased. Expression of ICAM-1, matrix metallopeptidase 9 (MMP-9) and integrin β1, three SRF targets and key regulators of cell migration, and AQP1 in injured arteries was significantly weaker in Mkl1-/...Continue Reading

References

Dec 16, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Dean P StausChristopher P Mack
Mar 27, 2010·Carcinogenesis·Toshiyuki YoshioKenji Sobue
Dec 1, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Grazia P NicchiaMaria Svelto
Mar 23, 2013·Free Radical Biology & Medicine·Jixiang NiYunchao Su
Apr 9, 2013·The Journal of Clinical Investigation·Christine WeinlAlfred Nordheim
May 16, 2013·Development·Claudio A FrancoZhenlin Li
Dec 18, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cristina Esteva-FontA S Verkman
Dec 18, 2013·Journal of Mammary Gland Biology and Neoplasia·Ali Mobasheri, Richard Barrett-Jolley
Oct 31, 2014·Annals of Clinical and Translational Neurology·Takakuni MakiMasafumi Ihara
Nov 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alice da Cunha Morales ÁlvaresSonia Maria de Freitas
Nov 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mozhgan Rezaie KanaviArthur S Polans

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