The expression of multidrug resistance-associated protein (MRP) in pancreatic adenocarcinoma cell lines

Cancer Letters
D W MillerT Lawson

Abstract

The presence of P-glycoprotein (P-gp) and multiple drug resistance-associated protein (MRP) was examined in four human pancreatic adenocarcinoma cell lines (PANC-1, BxPC-3, AsPC-1, and Capan-1). Cellular accumulation of rhodamine 123 and [3H]vincristine were used to determine functional activity of P-gp and MRP, respectively. None of the cells showed any evidence of P-gp in the rhodamine 123 cellular accumulation assays. In contrast, PANC-1, BxPC-3 and AsPC-1 did display an increased accumulation of [3H]vincristine following treatment with either cyclosporin A or verapamil. Western blot analysis confirmed the expression of MRP, and little, if any, measurable P-gp in the cell lysates. These studies suggest that intrinsic drug resistance in pancreatic duct cancer may be due in part to the presence of MRP.

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Citations

Feb 28, 2002·European Journal of Pharmacology·Nagesh Bandi, Uday B Kompella
Jan 22, 2003·Advanced Drug Delivery Reviews·Yan ZhangDonald W Miller
Jan 7, 2004·Pancreas·Thomas SchaarschmidtRainer Wacke
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Apr 9, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Menq-Rong WuChung-Yi Yang
Jun 26, 2004·The Journal of Pharmacology and Experimental Therapeutics·Yan ZhangDonald W Miller
Mar 17, 2020·Frontiers in Pharmacology·Melis Debreli CoskunShaker A Mousa
Sep 29, 2019·International Journal of Molecular Sciences·Ivan RanđelovićJózsef Tóvári
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Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas SchluepMark E Davis

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