The expression of NF-kappaB, Ki-67 and MMP-9 in CCOT, DGCT and GCOC

Oral Oncology
Yanling GongXinming Chen

Abstract

Calcifying odontogenic cysts (COCs) represent a group of rare odontogenic lesions with a diversity of clinicopathological and behavioral features. According to the WHO classification of head and neck tumors in 2005, COC has been divided into calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC). With few reports available on its immunohistochemical profile, this study investigated the histopathological features and the expression of nuclear factor kappaB (NF-kappaB), Ki-67 and matrix metalloproteinase-9 (MMP-9) in CCOT, DGCT and GCOC. According to the WHO classification of head and neck tumors in 2005, 26 cases of the so-called COC were diagnosed as CCOT (n=14), DGCT (n=7) and GCOC (n=5), respectively. The specimens of 26 COCs and 10 classic ameloblastomas (as control group) were examined by immunohistochemistry using anti-NF-kappaB p65, anti-Ki-67 and anti-MMP-9 antibodies and by in situ hybridization(ISH)using anti-MMP-9 mRNA probes. Immunohistochemical reactivity for NF-kappaB was mainly detected in the cytoplasm of tumor cells, and nuclear reactivity was only seen in few tumor cells in COC and classic ameloblastomas. Rate of nuclear staining was less tha...Continue Reading

References

Jan 1, 1971·Nihon Koku Geka Gakkai zasshi·Y MatsumotoN Mizuno
Dec 22, 1999·Oncogene·B Rayet, C Gélinas
Feb 7, 2001·Journal of the National Cancer Institute·M Hidalgo, S G Eckhardt
Mar 21, 2002·Histopathology·D C Brown, K C Gatter
Jan 25, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hiroyuki KumamotoKiyoshi Ooya
Feb 13, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Shabnum MeerHasiena Ali
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoki YamanakaMitsuo Katano
Jul 17, 2004·Neoplasia : an International Journal for Oncology Research·Sanjeev ShuklaSanjay Gupta
Apr 9, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hiroyuki Kumamoto, Kiyoshi Ooya

❮ Previous
Next ❯

Citations

Nov 23, 2010·Head and Neck Pathology·Patricia DevilliersJoel K Cure
Jan 6, 2011·Journal of Oral Science·Shadi SaghafiMonavar Afzal-Aghaee
Nov 21, 2014·Head and Neck Pathology·Mary S Richardson, Susan Muller
Nov 21, 2014·Head and Neck Pathology·Keith D Hunter, Paul M Speight
Nov 16, 2010·Annals of Diagnostic Pathology·Hélder Antônio Rebelo PontesDécio dos Santos Pinto Júnior
Dec 3, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Chong Huat SiarKok Han Ng
Oct 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qian ZhangSung Woo Kim
Sep 8, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Marcelo Macedo CriveliniAdriano Motta Loyola
Aug 9, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Pedro Paulo de Andrade SantosLélia Batista de Souza
Oct 22, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Hye-Jung YoonSeong-Doo Hong
Feb 4, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Fábio C ProsdócimiKatiúcia B S Paiva
Nov 22, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sergio Iván Tobón-ArroyaveGloria Amparo Flórez-Moreno
Mar 27, 2019·Clinical Oral Investigations·Ana Cláudia Garcia RosaVera Cavalcanti de Araújo
Jun 16, 2021·Head and Neck Pathology·Gustavo de Souza VieiraDanielle Castex Conde

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Constantino Ledesma-MontesAbelardo Meneses-García
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Bin-Bin Li, Yan Gao
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Shabnum MeerHasiena Ali
© 2022 Meta ULC. All rights reserved