Abstract
We aim to examine p63 expression in basal cell carcinomas (BCCs) and to investigate association with their histopathological differentiation subtypes. Eighty-four BCCs were classified according to the histopathologic differentiation subtypes. Immunohistochemistry using monoclonal antibody against p63 was performed. In nontumoral skin, p63 expression was consistently seen in basal/suprabasal cells of epidermis, hair matrix cells, and outer root sheath of the hair follicle. In BCCs, the cases were distributed as 47 undifferentiated, 28 differentiated (16 adenoid and 12 keratotic), and nine superficial. The nuclear p63 expression was negative in two cases, whereas 64 BCCs (76.2%) showed homogeneous p63 immunostaining. There was no statistically significant difference between p63 expression and histological differentiation subtypes (p > 0.05). The expression of p63 was found strongly and diffuse in 72.3% of solid undifferentiated and 82.1% differentiated and in 77.8% of superficial type BCCs. p63 is consistently expressed in epidermal basal/suprabasal and adnexal basal cells. Most BCCs have higher homogeneous p63 expression than nontumoral epidermis, which is not changed according to histological differentiation subtypes. Thus, ove...Continue Reading
References
Aug 7, 1997·Oncogene·W C WeinbergC Deng
Dec 14, 1999·The Journal of Investigative Dermatology·R ParsaH Green
Feb 5, 2000·Carcinogenesis·P A HallN M Kernohan
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·G PellegriniM De Luca
Sep 5, 2001·Journal of Dermatological Science·R P DellavalleP Walsh
Dec 6, 2001·The International Journal of Biochemistry & Cell Biology·Natalie A Little, Aart G Jochemsen
Oct 3, 2002·Journal of Cutaneous Pathology·Jorge S Reis-FilhoFernando C Schmitt
Jan 22, 2003·Journal of Cutaneous Pathology·Miki Tsujita-KyutokuAiro Tsubura
Mar 4, 2003·Journal of Cellular and Molecular Medicine·E RaduL M Popescu
Jul 29, 2003·Virchows Archiv : an International Journal of Pathology·Jorge S Reis-FilhoFernando C Schmitt
Dec 24, 2003·Journal of Cutaneous Pathology·Hina S QureshiChan K Ma
Jan 20, 2004·Genes & Development·Maranke I KosterDennis R Roop
Feb 6, 2004·Journal of Dermatological Science·Maranke I Koster, Dennis R Roop
Mar 23, 2004·Carcinogenesis·Matthew D Westfall, Jennifer A Pietenpol
Jul 13, 2004·Molecular Genetics and Genomics : MGG·B De FeliceC Pinelli
Jul 23, 2004·Journal of Cutaneous Pathology·Hye-Rim ParkYoung Euy Park
Jul 24, 2004·The British Journal of Dermatology·Y TakeuchiO Ishikawa
Sep 24, 2004·Current Opinion in Genetics & Development·Xing Dai, Julia A Segre
Sep 25, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Doina IvanVictor G Prieto
Oct 2, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·David A WroneRonald L Moy
Jan 22, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Casimir BambergerSabine Werner
Citations
Apr 20, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Deepa T PatilSteven D Billings
Aug 2, 2007·The American Journal of Dermatopathology·Ki-Young SuhPedram Gerami
Jan 4, 2012·Pediatric Dermatology·Giovanni ZoccaliMaurizio Giuliani
Sep 6, 2014·PloS One·Natasha T HillMadhavi P Kadakia
Dec 7, 2010·The British Journal of Dermatology·K Sellheyer
Jul 8, 2009·Diagnostic Cytopathology·Deborah J Chute, Edward B Stelow
May 29, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Nauman Rauf KhanSaima Chaudhry
Jun 13, 2015·Cell Death & Disease·N T HillM Kadakia
Nov 21, 2019·International Journal of Molecular Sciences·Artem SmirnovEleonora Candi
Feb 26, 2016·International Journal of Surgical Pathology·Harim Tavares Dos SantosAlbina Altemani
Jul 31, 2019·Nature Medicine·Kathryn E YostHoward Y Chang
Apr 10, 2017·Virchows Archiv : an International Journal of Pathology·Annikka WeissferdtCesar A Moran