The expression of PD-1 ligands and IDO1 by macrophage/microglia in primary central nervous system lymphoma.

Journal of Clinical and Experimental Hematopathology : JCEH
Yuko MiyasatoYoshihiro Komohara

Abstract

Recent progress in anti-tumor immunotherapy has focused on the significance of the tumor microenvironment in tumor progression and resistance to chemo/radio-therapy. Myeloid cells such as macrophages are predominant stromal components in hematological malignancies. In the present study, we investigated the regulation of programmed death-1 (PD-1) ligand expression in primary central nervous system lymphoma (PCNSL) using PCNSL cell lines and human monocyte-derived macrophages. TK PCNSL cell line-derived soluble factors induced overexpression of PD-1 ligands, indoleamine 2,3-dioxygenase (IDO1), and several other cytokines in macrophages. The expression of PD-1 ligands was dependent on the activation of signal transducer and activator of transcription 3. PD-L1 and IDO1 were overexpressed by macrophage/microglia in PCNSL tissues, and gene expression profiling indicated that IDO1 expression was positively correlated with the expression of macrophage and lymphocyte markers. Macrophage-derived factors did not influence the proliferation or chemo-sensitivity of cell lines. These data suggest that the expression of immunosuppressive molecules, including PD-1 ligands and IDO1, by macrophage/microglia may be involved in immune evasion of l...Continue Reading

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Citations

May 28, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Satoshi KimuraToshiyuki Nakayama
Oct 1, 2019·Journal of Clinical and Experimental Hematopathology : JCEH·Hiroto TakeyaYoshihiro Komohara
Oct 9, 2019·Current Opinion in Neurology·K Grace Ho, Christian Grommes
May 23, 2020·Scientific Reports·Yasuo TakashimaRyuya Yamanaka
Aug 30, 2019·Nature Communications·Anna GalstyanJulia Y Ljubimova
Apr 17, 2019·International Journal of Molecular Sciences·Priyanka Chauhan, James R Lokensgard
Nov 12, 2019·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshihiro Komohara, Mamoru Harada
Jul 3, 2021·Cancers·Hans-Georg WirschingPatrick Roth

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