The expression of RAGE and EN-RAGE in leprosy

The British Journal of Dermatology
M-H KimS N Cho

Abstract

Extracellular newly identified RAGE-binding protein (EN-RAGE) is a ligand of the receptor for advanced glycation endproducts (RAGE) and has been termed S100A12. The ligation of EN-RAGE with RAGE on the endothelium, mononuclear phagocytes and lymphocytes triggers cellular activation with the generation of the key proinflammatory mediators interleukin (IL)-1beta and tumour necrosis factor (TNF)-alpha. The aim of this study was to investigate the presence of RAGE and EN-RAGE, their spatial localization and their coexpression in leprosy lesions. Immunohistochemistry and confocal laser scanning microscopy were used to evaluate the expression of RAGE and EN-RAGE in leprosy. By enzyme-linked immunosorbent assay, RAGE and EN-RAGE were detected in the serum. (1) In the multibacillary (MB) and paucibacillary (PB) groups, the level of RAGE production was significantly higher than in patients with atypical mycobacterial infection or sarcoidosis (P < 0.01). In the MB group, the production of RAGE was higher than in the PB group (P < 0.01), and it was higher in patients without the lepra reaction than in patients with the lepra reaction (P < 0.05). (2) In MB, PB and atypical mycobacterial infection, the level of EN-RAGE production was signif...Continue Reading

References

Jan 1, 1991·Annual Review of Physiology·J A Cooper
May 21, 1993·Science·T P Stossel
Apr 16, 1996·Biochemical and Biophysical Research Communications·T MartiM Y Gallin
Aug 5, 1996·Biochemical and Biophysical Research Communications·E C IlgC W Heizmann
Aug 28, 1999·The Journal of Biological Chemistry·T VoglJ Roth
Nov 24, 1999·Infection and Immunity·J D GottschA L Scott
Jun 9, 2000·The Journal of Investigative Dermatology·A MirmohammadsadeghU R Hengge
Sep 7, 2000·Biochemical and Biophysical Research Communications·M J Robinson, N Hogg
Dec 8, 2000·Biochimica Et Biophysica Acta·A M SchmidtD M Stern
Mar 20, 2003·Microscopy Research and Technique·Rosario Donato
Mar 20, 2003·Microscopy Research and Technique·O V MorozI B Bronstein
Apr 18, 2003·Lancet·Dirk FoellJohannes Roth
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Thoralf WendtAnn Marie Schmidt
Jan 11, 2005·Rheumatology·R A Watts

❮ Previous
Next ❯

Citations

Apr 30, 2008·Amino Acids·Jens Pietzsch, Susan Hoppmann
Dec 27, 2011·The Pediatric Infectious Disease Journal·Keyi Liu, Michael E Pichichero
Jan 5, 2010·Oxidative Medicine and Cellular Longevity·Rebecca V VinceLeigh A Madden
Mar 17, 2015·Clinical Reviews in Allergy & Immunology·Edward S Chen, David R Moller
Dec 11, 2019·Chembiochem : a European Journal of Chemical Biology·Qian WangRupal Gupta
Jul 9, 2016·Current Opinion in Pulmonary Medicine·Edward S Chen
Jan 14, 2021·Antioxidants·Fabrizio GuarneriSebastiano Gangemi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.