The expression of self antigenic determinants: implications for tolerance and autoimmunity

Current Opinion in Immunology
M J Mamula, J Craft

Abstract

T lymphocytes respond to small peptides in the context of major histocompatibility molecules and a host of other cell-surface proteins on antigen-presenting cells. By design, therefore, T-cell responses are dependent on the efficient and accurate processing of both foreign and self peptides by antigen-presenting cells. This review examines the functions of T cells that may be specific for self peptides processed and presented under less than ideal conditions or outside the normal pathways of antigen processing. Do these T cells survive selection events and remain in the repertoire of normal lymphocytes? Moreover, can these cells become activated and are they important in the pathogenesis of autoimmunity?

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Citations

Mar 11, 1998·Current Opinion in Immunology·K S TungC Teuscher
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·R Gianani, N Sarvetnick
Aug 1, 1996·Immunological Reviews·V Barnaba
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Apr 5, 1997·Annals of the New York Academy of Sciences·R RothM J Mamula
Aug 1, 1997·Arthritis and Rheumatism·J Craft, S Fatenejad

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