The expression of suppressor of cytokine signaling 1 and 3 in fat and placental tissue from women with gestational diabetes

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Mariusz KuźmickiJacek Szamatowicz

Abstract

The suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of signaling pathways induced by cytokines, hormones and growth factors. In the present study we measured the expression of SOCS1, SOCS3, interleukin-6 (IL-6), IL-6 receptor, IL-8 and leptin mRNA in paired samples of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) and placental tissue obtained from 18 pregnant women with normal glucose tolerance (NGT) and 20 subjects with gestational diabetes mellitus (GDM), using quantitative RT-PCR. The patients with GDM had significantly higher IL-8 mRNA expression in VAT than the women with NGT (p = 0.007), whereas the expression of SOCS1, SOCS3 and other genes study did not differ significantly between the two groups. Stepwise regression analysis revealed that SOCS1 mRNA expression in VAT was significantly associated with prepregnancy BMI (β = -0.68, p = 0.03) and IL-8 mRNA expression (β = 0.66, p = 0.03), whereas SOCS3 mRNA expression in VAT was independently predicted by IL-6 mRNA expression (β = 0.94, p = 0.0002, R(2) = 0.88). In conclusion, our results did not show significant differences in SOCS1 and SOCS3 mRNA expression in adipose and placental tissue obtained from pregnant women with and w...Continue Reading

References

Jun 26, 1997·Nature·R StarrD J Hilton
Sep 7, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·A FestaS M Haffner
Oct 9, 1999·The Journal of Biological Chemistry·C BjørbaekJ S Flier
Jan 11, 2001·Gynecologic and Obstetric Investigation·N VitoratosG Creatsas
Mar 29, 2001·Diabetologia·A Kautzky-WillerW Waldhäusl
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·A W RobertsW S Alexander
Sep 13, 2001·Stem Cells·D L Krebs, D J Hilton
Sep 14, 2002·The Journal of Biological Chemistry·Liangyou RuiMorris F White
May 20, 2003·Nature Immunology·Ben A CrokerWarren S Alexander
Nov 1, 2003·Biochemical and Biophysical Research Communications·Claire LagathuMartine Caron
Mar 10, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Trine RanheimChristian A Drevon
Jun 8, 2004·The Journal of Biological Chemistry·Hang ShiJeffrey S Flier
May 3, 2005·Diabetologia·H Kolb, T Mandrup-Poulsen
Nov 25, 2005·Diabetes·Ole P Kristiansen, Thomas Mandrup-Poulsen
Feb 27, 2008·Diabetes Care·Thomas A BuchananRichard Watanabe

❮ Previous
Next ❯

Citations

May 16, 2014·The Journal of Endocrinology·Martha Lappas
Apr 26, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zehra Sema OzkanEkrem Sapmaz
Jun 27, 2015·PloS One·Natalia Wawrusiewicz-KurylonekMaria Gorska
Sep 4, 2018·American Journal of Reproductive Immunology : AJRI·Kathleen R HeimVikki M Abrahams
Sep 9, 2018·American Journal of Reproductive Immunology : AJRI·Daisy Leon-MartinezVikki M Abrahams
Nov 1, 2020·International Journal of Molecular Sciences·Simon KecksteinTheresa M Kolben
Jun 17, 2021·European Journal of Clinical Nutrition·Cara TrivettDilys J Freeman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.