The expression of surface antigen Leu 1 by ocular adnexal lymphoid neoplasms

American Journal of Ophthalmology
D M KnowlesC Y Wang

Abstract

Leu 1 is a surface membrane antigen expressed by benign systemic T cells, most cases of B-cell-derived chronic lymphocytic leukemia, and approximately one half of the systemic B-cell lymphomas. Benign systemic B cells are Leu 1-. Our studies showed that the percentage of Leu 1+ cells was essentially the same as the percentage of OKT3+E+ (T) cells in six ocular adnexal pseudolymphomas, strongly suggesting that the benign B cells in these lesions were similarly Leu 1-. These studies also showed that malignant B cells in six of 15 (40%) ocular B-cell lymphomas were Leu 1+. Thus, the expression of Leu 1 by some malignant ocular adnexal B cells but not by benign ocular adnexal B cells appears to be analogous to the situation for lymph nodal and other systemic B cells. Although the explanation for the existence of this shared determinant is unknown, Leu 1 expression may possess clinical and diagnostic significance as a marker of neoplastic B cells.

References

Jan 1, 1976·Scandinavian Journal of Immunology·R J WinchesterT Hoffman
May 1, 1979·American Journal of Ophthalmology·D M KnowlesJ P Halper
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Citations

Aug 1, 1982·American Journal of Ophthalmology·J H YeoS L Trokel
Feb 1, 1983·American Journal of Ophthalmology·D M Knowles, F A Jakobiec
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·Y Takano, M Okudaira
Dec 1, 1986·Ophthalmology·F A JakobiecD M Knowles
Nov 1, 1987·The Journal of Pathology·P A HallA G Stansfeld

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