The expression of the aurora-A gene and its significance with tumorgenesis in non-Hodgkin's lymphoma

Leukemia & Lymphoma
Yoshihiro YakushijinMasaki Yasukawa

Abstract

Non-Hodgkin's lymphoma (NHL) has a wide biological heterogeneity with various cell origin and biological features. Recent WHO classification of lymphoid neoplasms gives importance to immunological and cytogenetic features in addition to morphologic aspects of tumors. Several investigators have performed NHL subclassification based on other biological features of tumor cells. It is extremely important to clarify the proliferation mechanism of tumor cells, and understanding this mechanism may provide insight not only into the biology of tumors but also into the treatment strategy for NHL. Therefore, research focused on the cell cycle is one of the major approaches to the biology and the oncogenesis of NHL. The Aurora kinase family recently identified from Drosophila melamogaster is believed to be an essential kinase involved in mitotic cell cycles. Several groups have reported that Aurora kinases are overexpressed in some solid tumors, suggesting that Aurora kinases may be involved in tumor survival and proliferation. Here, we focus on the role of Aurora-A kinase in the tumorgenesis of NHL using our recent research data, and discuss the possibility of Aurora-A as a new molecular target of NHL treatment.

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Feb 7, 1997·Cell·A G PaulovichL H Hartwell
Feb 17, 1999·Genes & Development·Q L Deveraux, J C Reed
Sep 27, 2000·Current Topics in Developmental Biology·T M Goepfert, B R Brinkley
Feb 13, 2001·Trends in Cell Biology·R R AdamsW C Earnshaw
Nov 7, 2002·The Journal of Biological Chemistry·Jun ChenShi-Chung Ng
Nov 26, 2002·Immunological Reviews·Matthew J ScanlanYao-Tseng Chen

❮ Previous
Next ❯

Citations

Oct 22, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kedar V InamdarCarlos E Bueso-Ramos
Feb 16, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rashmi Kanagal-ShamannaKedar V Inamdar
Jul 1, 2005·Molecular and Cellular Biology·Chang-Tze Ricky YuChi-Ying F Huang
Feb 11, 2014·International Journal of Hematology·Andrew M Intlekofer, Anas Younes
Jul 18, 2009·Journal of Cancer Research and Clinical Oncology·John McLaughlinYasumichi Hitoshi
Sep 24, 2015·Pharmaceuticals·Natalie S Grover, Steven I Park
Mar 9, 2012·Expert Opinion on Investigational Drugs·Jonathan How, Karen Yee
Jun 25, 2014·Expert Opinion on Emerging Drugs·Sudy JahangiriPaul Barr
Jun 17, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul M BarrJonathan W Friedberg
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jonathan W FriedbergSteven H Bernstein
Jan 25, 2017·Blood·Alessandro Broccoli, Pier Luigi Zinzani
Feb 2, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Owen A O'ConnorUNKNOWN Lumiere Study Investigators
Oct 11, 2011·British Journal of Haematology·Sherif S Farag
Jan 4, 2017·Journal of the National Cancer Institute·Carla CasuloSteven Horwitz
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Haiyong Han, Daniel D Von Hoff

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.