PMID: 7520411Jun 1, 1994Paper

The expression of the B-cell marker mb-1 (CD79a) in Hodgkin's disease

Histopathology
P KorkolopoulouD Y Mason

Abstract

Recent evidence indicates that membrane-bound immunoglobulin on B lymphocytes is associated with a molecule which comprises the products of the mb-1 and B29 genes. This molecule is a highly specific marker for B-cells, presumably because of its central functional role in antigen triggering, and has recently been clustered as CD79a at the 5th Leucocyte Workshop. Recently there has been controversy surrounding reports of B-cell antigen expression by Reed-Sternberg and related cells, and we have therefore studied 108 cases of Hodgkin's disease immunohistochemically using a novel antibody which detects mb-1 protein in paraffin sections. The results were compared with those achieved using antibody L26 to detect CD20. The mb-1 protein was present in the neoplastic cells in all 14 cases of lymphocyte predominance Hodgkin's disease studied, and CD20 immunoreactivity was also found in seven of the eight cases of this subtype studied. Of the non-lymphocyte predominance cases, 20% (19/94) expressed mb-1 and 30% (20/67) CD20 in the Reed-Sternberg cells, but the cells positive for either of these two markers usually constituted only a very small proportion of the neoplastic population. However, in occasional cases (one of 94 for mb-1 and fi...Continue Reading

References

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Citations

Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George Z RassidakisAndreas H Sarris
Jun 25, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Parul BhargavaMarshall E Kadin
Jun 9, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·P G Chu, D A Arber
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·X YaoE S Jaffe
May 24, 2014·The American Journal of Surgical Pathology·Denise Hollman-HewgleyLawrence M Weiss
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·A BraeuningerM L Hansmann
Aug 10, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A F LauritzenE Ralfkiaer
Oct 3, 2002·The American Journal of Surgical Pathology·Emina TorlakovicJan Delabie
Jun 30, 2000·American Journal of Clinical Pathology·R LaiW S Etches
May 23, 1998·Annual Review of Immunology·R Küppers, K Rajewsky
Jun 15, 2007·International Journal of Hematology·Makoto SaitoMasanobu Morioka
Jul 10, 2020·Journal of Clinical and Experimental Hematopathology : JCEH·Akio SakataniTadashi Yoshino
Dec 25, 2010·Acta Microbiologica Et Immunologica Hungarica·J RajčániS Szathmary
Oct 16, 2007·The Journal of Pathology·S TedoldiT Marafioti
Nov 7, 2006·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Alexandar Tzankov, Stephan Dirnhofer
Sep 1, 2004·Archives of Pathology & Laboratory Medicine·Cherie H Dunphy

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