PMID: 6159381Nov 1, 1980Paper

The expression of the epithelial blood-group substances: normal and malignant tissues

Journal of Dental Research
D I GeorgeD E Lopatin

Abstract

The blood-group isoantigens are macromolecules localized to the plasma membranes of certain epithelial tissues. These substances are not detectable on the epithelium once it has undergone malignant transformation. Results of this investigation have demonstrated that the loss of detectability of the blood-group isoantigens does not appear to be related to a "masking" effect by an increase in surface sialic acid. Using fluorescein-labeled lectins specific for sugar subunits which are components of the blood-group oligosaccharide chain, it was found that the malignant cells and cells of the parabasal layer of normal oral epithelium had high levels of N-acetyl-D-glucosamine (GlcNAC), the subterminal sugar residue of the blood-group chain. The basal cells of normal epithelium and a minority of the malignant cells demonstrated levels of D-galactose-N-acetyl-D-galactosamine, which are the most proximal blood-group sugar subunits, as well as subunits of other membrane antigens. Our results indicate that malignant cells seem to be capable of synthesizing the blood-group oligosaccharide chains to the same level as the normal cells of the parabasal layer of stratified squamous epithelium. This level is just subjacent to the terminal D-gal...Continue Reading

References

Jan 1, 1979·Oral Surgery, Oral Medicine, and Oral Pathology·D I GeorgeR L Miller
Sep 28, 1978·The New England Journal of Medicine·D K PodolskyA M Cohen
Jul 1, 1974·Oral Surgery, Oral Medicine, and Oral Pathology·P I LiuL A Miller
Jun 1, 1972·American Journal of Clinical Pathology·I Davidsohn

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Citations

Jan 1, 1990·Archives of Dermatological Research·G MetzlerK Liebig
Jan 1, 1984·Differentiation; Research in Biological Diversity·P VedtofteW W Young
Jan 1, 1984·Differentiation; Research in Biological Diversity·P VedtofteW W Young
Sep 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T Saku, H Okabe
Oct 1, 1981·Scandinavian Journal of Dental Research·P Vedtofte, E Dabelsteen
Mar 1, 1989·Journal of Periodontal Research·M Hormia, I Virtanen
Oct 1, 1984·Scandinavian Journal of Dental Research·J Hietanen, O P Salo

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