PMID: 9645455Jun 30, 1998Paper

The expression of the mdm2 gene may be related to the aberration of the p53 gene in human hepatocellular carcinoma

Journal of Cancer Research and Clinical Oncology
S J QiuY K Liu

Abstract

The relationship between mdm2 gene expression and p53 gene mutation in hepatocellular carcinoma (HCC) and their correlation with the invasiveness of the disease were investigated in this study. Either the expression level of the mdm2 gene or the mutation rate of the p53 gene was higher in HCC than in paratumor liver tissues. Studies on the relationship between mdm2 and p53 revealed that mdm2 gene expression in HCC without p53 mutation was higher than when there was p53 mutation, while the p53 mutation rate in HCC with mdm2 overexpression was significantly lower than in HCC without mdm2 overexpression. Among 23 HCC with invasion, mdm2 gene overexpression was found in 6 patients while p53 mutation was found in the other 11 patients, and only 1 patient was found to have both mdm2 overexpression and p53 mutation. These results indicated that either mdm2 overexpression or p53 mutation may be related to the invasiveness of HCC. Considering that an autoregulatory feedback loop between the mdm2 and p53 genes may exist, wild-type P53 can induce the expression of mdm2 via a p53-binding site in the mdm2 gene, while MDM2 protein functions as a negative regulator of P53 protein. These results also suggest that mdm2 may be related to the hig...Continue Reading

Citations

Jun 24, 2014·Journal of Immunology Research·Mei LiuJian-Ying Zhang
May 14, 2011·Archives of Medical Research·Guo-Yuan LiuLong Yu
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jian ZhaoYajun Guo
Jan 31, 2003·Molecular Carcinogenesis·Sharon L RickettsWilliam B Coleman
Jan 31, 2002·World Journal of Gastroenterology : WJG·Z Y Tang
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhuo ZhangRuiwen Zhang

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