The expression of the MSC-marker CD73 and of NF2/Merlin are correlated in meningiomas

Journal of Neuro-oncology
Elmar KirchesChristian Mawrin

Abstract

Mesenchymal stem cells (MSC) have been found in various cancers and were discussed to influence tumor biology. Cells fulfilling the complete MSC criteria, including surface marker expression (CD73, CD90, CD105) and tri-lineage differentiation, have been isolated solely from a low percentage of high-grade meningiomas. In contrast, pure co-expression of the surface-markers was relatively frequent, raising the question for an additional role of these membrane proteins in meningiomas. Therefore, here we analyzed the expression of CD73, CD90 and CD105 in a series of meningiomas of all grades. Although no significant association of any marker with meningeal tumor growth per se or with tumor-grade was observed, we detected a positive Pearson correlation (r = 0.55, p ≤ 0.05) in low-grade tumors between CD73 and the most relevant tumor suppressor NF2/Merlin, supported by a tendency of lower CD73 expression in cases with allelic losses at the NF2-locus, which express significantly lower NF2/Merlin-mRNA (p ≤ 0.05). In two pairs of syngenous meningeal or meningioma cell lines with or without shRNA-mediated knockdown of NF2/Merlin a nearly complete loss of CD73 mRNA expression was observed after the knockdown (p ≤ 0.001). This suggested tha...Continue Reading

References

Jun 1, 1994·Genes, Chromosomes & Cancer·M H RuttledgeJ P Dumanski
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·R G WeberP Lichter
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah E DuffShant Kumar
Jun 21, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sylvia PüttmannWerner Paulus
Jun 28, 2007·Acta Neuropathologica·Valeria BarresiGiovanni Tuccari
Oct 5, 2007·Nature·Antoine E KarnoubRobert A Weinberg
Feb 20, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Valeria BarresiGiovanni Tuccari
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nikolaos A DallasLee M Ellis
Oct 28, 2008·Neoplasia : an International Journal for Oncology Research·Katherine StriedingerAnita Lal
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Kei ShinagawaKazuaki Chayama
Sep 3, 2010·Journal of Neuro-oncology·Christian Mawrin, Arie Perry
Sep 7, 2011·Journal of Neuro-oncology·Dezhi HuLiangfu Zhou
Oct 6, 2011·International Journal of Oncology·Shinji TsukamotoYasuhito Tanaka
Mar 1, 2012·Molecular Medicine Reports·Serban ComşaMarius Raica
Feb 15, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Doreen PachowChristian Mawrin
Mar 20, 2013·Clinical & Experimental Metastasis·Li WangZhimin Shao
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sherene LoiJohn Stagg
Aug 8, 2013·International Journal of Oncology·Hyo-Yeol LimSeok-Gu Kang
Aug 16, 2014·BioMed Research International·Zhao-wei GaoHui-zhong Zhang
May 21, 2015·American Society of Clinical Oncology Educational Book·Christian MawrinMatthias Preusser
Sep 10, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Akihiro InoueTakanori Ohnishi
Sep 13, 2015·Cancer Research·Martin TurcotteJohn Stagg
Dec 8, 2015·The Journal of Clinical Investigation·Jessica L BowserRussell R Broaddus
Dec 24, 2015·International Journal of Molecular Sciences·Ki-Jong RheeYoung Woo Eom
May 23, 2016·Current Opinion in Pharmacology·Bertrand AllardJohn Stagg
Jun 21, 2016·Oncogene·F Di Virgilio, E Adinolfi
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fatemeh NoroziNajmaldin Saki
Aug 25, 2016·Oncotarget·Zhen-Hu RenChen-Ping Zhang

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