The expression of the neurogenic locus Notch during the postembryonic development of Drosophila melanogaster and its relationship to mitotic activity

Journal of Neurogenetics
K Markopoulou, S Artavanis-Tsakonas

Abstract

The molecular analysis of the Notch locus of Drosophila melanogaster demonstrated that it codes for a protein which shows homology to the epidermal growth factor as well as to the products of certain yeast genes involved in the control of the cell cycle (Wharton et al., 1985a; Breeden and Nasmyth, 1987). The structure of the protein suggests that Notch is involved in a cell interaction mechanism which controls the differentiation of several different tissues during development. Here we examine Notch expression during imaginal development using in situ hybridization to tissue sections and demonstrate that Notch is not expressed ubiquitously during the postembryonic stages, but rather is confined to specific tissues. During the larval and early pupal period Notch transcripts are predominantly localized in the imaginal discs and the central nervous system. In the middle and late pupal period the signal levels in these tissues drop dramatically and in the adult animal Notch transcripts are essentially detected only in the ovaries. In the larval stages the pattern of Notch expression appears to be closely correlated with mitotically active tissues, while in later stages this correlation appears less strict. The findings reported her...Continue Reading

References

Sep 1, 1975·Genetics·D L Shellenbarger, J D Mohler
Oct 15, 1976·Developmental Biology·D F ReadyS Benzer
Jan 1, 1985·Cold Spring Harbor Symposia on Quantitative Biology·B YedvobnickS Artavanis-Tsakonas
Oct 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K UiT Miyake
Feb 1, 1985·Developmental Biology·B G GrimwadeS Artavanis-Tsakonas
Jan 1, 1970·Advances in Genetics·T R Wright
Mar 1, 1968·Experimental Gerontology·J Delcour, M J Heuts
Nov 26, 1965·Science·W J Welshons
Sep 1, 1983·Cell·S KiddM W Young
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Artavanis-TsakonasB Yedvobnick
Dec 1, 1984·Journal of Neurogenetics·U Dietrich, J A Campos-Ortega
Dec 1, 1977·Wilhelm Roux's Archives of Developmental Biology·M Mandaravally Madhavan, Howard A Schneiderman
Mar 1, 1983·Wilhelm Roux's Archives of Developmental Biology·Ruth LehmannJosé A Campos-Ortega

❮ Previous
Next ❯

Citations

Dec 1, 1992·Developmental Biology·A G ReaumeJ Rossant
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J F de CelisA García-Bellido
Mar 1, 1995·Neuron·R I DorskyW A Harris
Mar 1, 1996·The Journal of Experimental Zoology·A T SchmidB Yedvobnick
Jan 24, 2006·Nature Reviews. Neuroscience·Angeliki Louvi, Spyros Artavanis-Tsakonas
Feb 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K SawamotoH Okano
Jan 1, 1997·Molecular and Cellular Neurosciences·G Weinmaster

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.