The expression of tissue-type plasminogen activator, matrix metalloproteases and endogenous inhibitors in the central nervous system in multiple sclerosis: comparison of stages in lesion evolution

Journal of Neuropathology and Experimental Neurology
M L CuznerJ Newcombe

Abstract

The expression of tissue-type plasminogen activator (t-PA) and a number of metalloproteases as well as plasminogen activator inhibitor-1 (PAI-1) and tissue inhibitor of metalloproteases-1 (TIMP-1) was analyzed in the central nervous system (CNS) of normal control and multiple sclerosis (MS) cases by immunohistopathology. The expression of t-PA was detectable only in the blood vessel matrix in control white matter, but positive infiltrating mononuclear cells were also observed in MS white matter and primary lesions. In active plaques this pattern converted to strong positivity of foamy macrophages in areas of demyelination, declining in chronic lesions. In general PAI-1 expression paralleled that of t-PA. Gelatinase A and B were detected predominantly in astrocytes and microglia throughout normal control white matter, with additional positive mononuclear cells in perivascular cuffs in MS white matter. In the demyelinating lesion there is widespread prominent expression of gelatinase B in reactive astrocytes and macrophages, which persists in astrocytes in the chronic lesion. TIMP-1 was also present in the vessel matrix and in lesional macrophages. These observations on the coexpression of enzymes and inhibitors of the matrix deg...Continue Reading

Citations

Nov 15, 2001·Annals of Neurology·J W PrineasB P Morgan
Aug 31, 2002·Glia·Gary A Rosenberg
Mar 21, 2006·Acta Neuropathologica·Maria Diaz-SanchezMargaret M Esiri
Nov 19, 2004·Journal of Neurology·Hans-Peter HartungYannis Zoukos
Aug 9, 2012·Cellular and Molecular Neurobiology·Manao KinoshitaSchuichi Koizumi
Sep 5, 2013·Acta neurologica Belgica·Mohammad A JavaidZeeshan Sheikh
Jul 20, 2002·Journal of the Neurological Sciences·I NelissenG Opdenakker
Jul 30, 1999·Journal of the Neurological Sciences·F O AkenamiA Vaheri
Sep 2, 2000·Journal of Neuroimmunology·G MartinoG Comi
Mar 7, 2003·Journal of Neuroimmunology·Carlo AvolioMaria Trojano
Jul 17, 2003·Journal of Neuroimmunology·Jorge Correale, María de los Milagros Bassani Molinas
Mar 1, 2000·Journal of Neuroimmunology·A Bar-OrD A Hafler
Mar 14, 1998·Trends in Neurosciences·V W YongD R Edwards
Mar 24, 1999·Trends in Neurosciences·J J ArchelosH P Hartung
May 15, 2002·Brain Research. Molecular Brain Research·E M MuirJ H Rogers
Jul 25, 2003·Brain Research. Molecular Brain Research·Bo FranzénIna Schuppe-Koistinen
Jul 20, 2002·Clinical Neurology and Neurosurgery·Ariel Miller, Yanina Galboiz
Aug 12, 2003·Brain Research Bulletin·F Sellebjerg, T L Sørensen
Sep 10, 2003·Nihon rinsho. Japanese journal of clinical medicine·Hirofumi Ochi
Sep 9, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M R Del BigioM Altumbabic
Nov 17, 2001·International Immunopharmacology·K A Brown
Apr 10, 2007·Biochemistry·Sachiko I BlaberMichael Blaber
Jul 4, 2001·Nature Reviews. Neuroscience·V W YongD R Edwards
Jul 27, 1999·Neuropathology and Applied Neurobiology·N J GutowskiM L Cuzner
Oct 29, 1998·Mediators of Inflammation·V A VincentA M Van Dam
Mar 5, 2003·Journal of Neurotrauma·Yumiko AbeTomoatsu Kimura
Mar 12, 2013·Antioxidants & Redox Signaling·Djordje Miljković, Ivan Spasojević
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J H HeoG J del Zoppo
Dec 1, 1999·Annals of the Rheumatic Diseases·C LockL Steinman
Dec 28, 1999·The British Journal of Ophthalmology·A M El-AsrarG Opdenakker
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·T KanesakaS Kuwabara
Oct 27, 1999·Canadian Journal of Physiology and Pharmacology·M A ForgetR Béliveau
Apr 20, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Haoqian ZhangLinda J Noble-Haeusslein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.