PMID: 6399697Jul 1, 1984Paper

The expression of transformation-related protein p53 and p53-containing mRNA in murine RAW117 large cell lymphoma cells of differing metastatic potential

Clinical & Experimental Metastasis
V RotterG L Nicolson

Abstract

The relationship between the expression of a transformation-related cellular-encoded phosphoprotein, p53, and the potential to form distant metastases was investigated in Abelson murine leukemia virus-transformed murine large cell lymphoma sublines of differing metastatic behaviors. Low metastasis RAW117-P and high metastasis RAW117-H10 cells were labeled with 35S-methionine, and several anti-p53 monoclonal antibodies were used to immunoprecipitate p53 from the cell lysates. Using these procedures, similar amounts of p53 were detected in the RAW117-P and -H10 cells. In addition, the expression of 2.0 Kb mRNA containing p53-specific sequences was equivalent in RAW117-P and -H10 cells. The results indicate that p53 expression, although apparently required for neoplastic transformation, is not quantitatively related to metastatic behavior in RAW117 large cell lymphoma cells.

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Citations

Jan 1, 1987·Clinical & Experimental Metastasis·S S JoshiK W Brunson
Jan 1, 1990·Molecular Aspects of Medicine·T N Dear, R F Kefford
Dec 1, 1991·British Journal of Haematology·M A RodriguezA B Deisseroth
Apr 1, 1988·Journal of Cellular Biochemistry·R A LaBicheG L Nicolson
Jan 1, 1995·Acta Oncologica·S Paydas

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