Abstract
During development of the peripheral nervous system, the extracellular matrix molecule tenascin has been found to be closely associated with growing axons. However, its origin and function in peripheral nerve formation are far from clear. In this study, we examined the expression of tenascin during outgrowth of sensory, motor and sympathetic preganglionic axons, and assessed its origin and function in peripheral nerve formation. During outgrowth of sensory and motor axons, a high concentration of tenascin and its mRNA was found to surround sensory and motor axons in the newly formed spinal nerves. The source of this tenascin was examined through a series of surgical manipulations. Neural crest removals did not alter the distribution of tenascin protein or its mRNA surrounding the spinal nerves. Transplantation of quail somites into chick embryos showed that, similar to the distribution of tenascin, there is a high concentration of somitic cells surrounding the spinal nerves. Moreover, somite removals resulted in a reduction of the tenascin and tenascin mRNA surrounding the spinal nerves. Taken together, these results suggest that the majority of the tenascin surrounding the spinal nerves is of somitic origin. Possible functions...Continue Reading
References
Oct 1, 1992·Genes & Development·Y SagaS Aizawa
Nov 1, 1990·Neuron·A Faissner, J Kruse
Feb 1, 1991·Journal of Neuroscience Research·R Martini, M Schachner
Jun 1, 1991·The Journal of Cell Biology·A LochterA Faissner
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S S TanG M Edelman
May 1, 1986·The Journal of Cell Biology·K L CrossinG M Edelman
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S S TanG M Edelman
Oct 1, 1988·Journal of Neuroscience Research·M Bronner-Fraser
Oct 20, 1989·Cell·J SpringR Chiquet-Ehrismann
May 1, 1985·Developmental Biology·K W Tosney, L T Landmesser
Nov 4, 1988·Science·J Dodd, T M Jessell
Dec 22, 1988·Nature·M Tessier-LavigneT M Jessell
Jun 1, 1988·Developmental Biology·K W Tosney
Nov 1, 1974·Developmental Biology·N M Le Douarin, M A Teillet
Sep 21, 1984·Science·C S GoodmanJ B Thomas
Mar 1, 1993·The Journal of Cell Biology·H P Erickson
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON
Citations
Sep 5, 1998·Brain Research. Developmental Brain Research·A U ZaidiB S Zielinski
Feb 13, 2001·Brain Research Bulletin·C E Krull, S A Koblar
Aug 20, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jörn SchweitzerCatherina G Becker
Apr 25, 2000·Developmental Biology·R R Bernhardt, M Schachner
Nov 24, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R R BernhardtM Schachner
May 26, 1997·The Journal of Comparative Neurology·E B CornbrooksC J Forehand