Abstract
Sensorineural hearing loss, as a consequence of acoustic trauma, aging, genetic defects or ototoxic drugs, is highly associated with irreversible damage of cochlear hair cells (HCs) and secondary degeneration of spiral ganglion (SG) cells. Cochlear implants (CIs), which bypass the lost HC function by direct electrical stimulation of the remaining auditory neurons, offer an effective therapy option. Several studies imply that components of the extracellular matrix (ECM) have a great impact on the adhesion and growth of spiral ganglion neurons (SGNs) during development. Based on these findings, ECM proteins might act as bioactive CI substrates to optimize the electrode-nerve interface and to improve efficacy of these implants. In the present study, we focused on the ECM glycoproteins Tenascin-C (TN-C), Laminin (LN), and Fibronectin (FN), which show a prominent expression along the growth route of SGNs and the niche around HCs during murine postnatal development in vivo. We compared their influence on adhesion, neurite length, and neurite number of SGNs in vitro. Moreover, we studied the expression of the chondroitin sulfate proteoglycan (CSPG) dermatan sulfate-dependent proteoglycan-1 (DSD-1-PG), an interaction partner of TN-C. I...Continue Reading
References
Jan 17, 1992·Brain Research. Developmental Brain Research·N K WoolfA F Ryan
Nov 1, 1990·Neuron·A Faissner, J Kruse
Aug 1, 1994·The Journal of Cell Biology·A FaissnerM Schachner
Feb 1, 1996·The Journal of Cell Biology·B GötzA Faissner
Mar 1, 1997·Hearing Research·D Cosgrove, K D Rodgers
Oct 10, 1997·Cell and Tissue Research·A Faissner
Apr 2, 1999·The Journal of Comparative Neurology·D S WhitlonM Kusakabe
Apr 6, 1999·Hearing Research·V Tsuprun, P Santi
May 13, 1999·Hearing Research·D J Swartz, P A Santi
Dec 11, 1999·The Laryngoscope·D G WeinbergerM Baethmann
Mar 14, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·A Joester, A Faissner
Jun 1, 2001·Audiology & Neuro-otology·C AletseeA F Ryan
Jul 27, 2001·Hearing Research·V Tsuprun, P Santi
Aug 17, 2001·Hearing Research·K D RodgersD Cosgrove
Apr 13, 2002·Hearing Research·Christoph AletseeAllen F Ryan
Sep 15, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·Pamela C Roehm, Marlan R Hansen
Jan 13, 2006·Journal of Neurobiology·Rodrigo Martinez-MonederoAlbert S B Edge
Sep 22, 2006·Audiology & Neuro-otology·Rachael T RichardsonStephen O'Leary
Mar 7, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Stefan VolkensteinA Neumann
Apr 28, 2009·Molecular and Cellular Neurosciences·Melanie Michele, Andreas Faissner
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa R AndrewsJames W Fawcett
May 22, 2009·Glia·Tim CzopkaAndreas Faissner
Jun 11, 2009·Neuron Glia Biology·Sonia SiddiquiAndreas Faissner
Jul 31, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Helen B TreloarCharles A Greer
Sep 2, 2009·Journal of Neural Engineering·Stephen J O'LearyHugh J McDermott
Dec 29, 2009·Frontiers in Bioscience (Landmark Edition)·Nobuaki MaedaMaki Ishii
Feb 27, 2010·Drug Discovery Today·Hinrich StaeckerCarolyn Garnham
Sep 29, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Stefan VolkensteinStefan Heller
Jan 31, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Uta ReichGünter Reuter
Aug 13, 2013·PloS One·Yali ZhaoQiuju Wang