The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers

Cancer Cell International
Jing ChenJing-Jing Jing

Abstract

Non-receptor protein tyrosine phosphatases (PTPNs) are a set of enzymes involved in the tyrosyl phosphorylation. The present study intended to clarify the associations between the expression patterns of PTPN family members, and diagnosis as well as the prognosis of digestive tract cancers. Oncomine and Ualcan were used to analyze PTPN expressions. Data from The Cancer Genome Atlas (TCGA) were downloaded through UCSC Xena for validation and to explore the relationship of the PTPN expression with diagnosis, clinicopathological parameters and survival of digestive tract cancers. Gene ontology enrichment analysis was conducted using the DAVID database. The gene-gene interaction network was performed by GeneMANIA and the protein-protein interaction (PPI) network was built using STRING portal coupled with Cytoscape. The expression of differentially expressed PTPNs in cancer cell lines were explored using CCLE. Moreover, by histological verification, the expression of four PTPNs in digestive tract cancers were further analyzed. Most PTPN family members were associated with digestive tract cancers according to Oncomine, Ualcan and TCGA data. Several PTPN members were differentially expressed in digestive tract cancers. For esophageal c...Continue Reading

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Citations

Jan 21, 2021·Drug Design, Development and Therapy·Xiangxun ChenLin Yang

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Methods Mentioned

BETA
PCR
xenograft

Software Mentioned

Ualcan
Oncomine
R
Search Tool for the Retrieval STRING
SPSS
Cytoscape
STRING
GeneMANIA

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